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Merck
CN

P1306

Sigma-Aldrich

Peptide YY human

≥97% (HPLC), synthetic

别名:

PYY, Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2

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关于此项目

经验公式(希尔记法):
C194H295N55O57
化学文摘社编号:
分子量:
4309.75
MDL编号:
UNSPSC代码:
51111800
NACRES:
NA.32
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生物来源

synthetic

质量水平

方案

≥97% (HPLC)

表单

solid

UniProt登记号

储存温度

−20°C

基因信息

human ... PYY(5697)

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2

一般描述

Human peptide YY (PYY) is secreted by mucosal L cells in the distal ileum, colon and rectum. It consists of 36 amino acids. The gene encoding PYY is localized on human chromosome 17q21.1.

应用

Peptide YY human has been used as a supplement in Roswell Park Memorial Institute medium (RPMI medium) to culture pancreatic duct-derived cells.

生化/生理作用

Gut hormone that inhibits both secretin and cholecystokinin-stimulated pancreatic secretion. Endogenous nonselective agonist at NPY receptors.
Human peptide YY (PYY) has a role in food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes. PYY also has a role in energy homeostasis.
Inhibits secretin and cholecystokinin-stimulated pancreatic secretion;endogenous nonselective agonist at NPY receptors.

其他说明

Lyophilized from 0.1% TFA in H2O

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Rapid and Efficient In Vitro Generation of Pancreatic Islet
Progenitor Cells from Nonendocrine Epithelial Cells in the
Adult Human Pancreas
JOSEPHINE S. D?ALESSANDRO
Stem Cells and Development (2007)
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study.
Cahill F
PLoS ONE (2014)
Genomic and gene expression signature of the pre-invasive
testicular carcinoma in situ
Kristian Almstrup
Cell and Tissue Research (2005)
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways.
Larraufie P
Cellular Microbiology (2017)
Alexandre Kazuo Kuniyoshi et al.
Toxicon : official journal of the International Society on Toxinology, 137, 114-119 (2017-08-02)
In Brazil, envenomation by Bothrops pitvipers is responsible for over 73% of snakebites, and their venom is a rich source of proteolytic enzymes. Most studies have demonstrated that Bothrops jararaca venom acts on macromolecular substrates, causing an imbalance in the

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