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Merck
CN

P1584

肽基精氨酸脱亚胺酶 来源于兔骨骼肌

buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)

别名:

蛋白质精氨酸亚氨基水解酶

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
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产品名称

肽基精氨酸脱亚胺酶 来源于兔骨骼肌, buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)

form

buffered aqueous glycerol solution

specific activity

≥200 units/mg protein (Bradford)

relevant disease(s)

arthritis (rheumatoid )

shipped in

dry ice

storage temp.

−70°C

Quality Level

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Application

肽基精氨酸脱亚胺酶已被用于一项评估了有前途的新型生物标志物,用于类风湿性关节炎的早期诊断的研究。 也有研究用于探讨牙周炎和类风湿关节炎的自身致病相关性。

Biochem/physiol Actions

在体外,钙是肽酰精氨酸脱亚胺酶活性所必需的

General description

肽基精氨酸脱亚胺酶是将精氨酸转化为瓜氨酸的酶。

Other Notes

一个单位将在55°C,pH 7.2下每小时从BAEE产生 1μN-α 摩尔苯甲酰瓜氨酸乙酯。

Physical form

溶液溶于 20 mM Tris-HCl,pH 7.4,含 10 mM 2-巯基乙醇、1 mM EDTA 和 10% 甘油

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

低风险生物材料
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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John G Routsias et al.
Rheumatology (Oxford, England), 50(7), 1189-1193 (2011-02-24)
Recently, a number of studies have pointed to a potential relationship between periodontitis (PO) and RA and vice versa. Both diseases are characterized by chronic inflammation, osseous destruction, damage of the supporting soft tissues, similar cellular immune responses and common
Murat Bozdag et al.
Bioorganic & medicinal chemistry letters, 23(3), 715-719 (2012-12-26)
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non
Nishant Dwivedi et al.
Annals of the rheumatic diseases, 73(3), 483-491 (2013-12-03)
Tolerance blocks the expression of autoantibodies, whereas autoimmunity promotes it. How tolerance breaks and autoantibody production begins thus are crucial questions for understanding and treatment of autoimmune diseases. Evidence implicates cell death and autoantigen modifications in the initiation of autoimmune
Leendert A Trouw et al.
Autoimmunity reviews, 12(2), 318-322 (2012-06-06)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints affecting about 0.5% of the general population. Early treatment in RA is important as it can prevent disease progression and irreversible damage of the
M Fujisaki et al.
Journal of biochemistry, 89(1), 257-263 (1981-01-01)
An enzyme which catalyzes the coversion of arginyl residues to citrullyl residues in protein was obtained from the extract of the epidermis of newborn rats. The enzyme required Ca2+ for its activity. The enzyme activity was enhanced in the presence

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