P1641
5α-孕烷-3β,11β,17α,21-四醇-20-酮
别名:
3β,11β,17α,21-四羟基-5α-孕甾-20-酮, 3β,5α-四氢皮质甾醇, 3β-别四氢皮质甾醇, Reichstein’s substance V
技术
HPLC: suitable
gas chromatography (GC): suitable
包装形式
neat
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Andrea Raffaelli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 278-285 (2005-11-29)
The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) is responsible for the interconversion of both the hormonally inactive cortisone and the active cortisol. This enzyme activity, which has implications in the pathogenesis of numerous diseases, is reflected in the ratio of tetrahydrometabolites of cortisol
Franciszek K Główka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 283-289 (2009-12-19)
11Beta-hydroxysteroid dehydrogenase isoform 2 (11beta-HSD2) is responsible for conversion of cortisol (F) to inactive cortisone (E). Disturbance of its activity can cause hypertension. To estimate 11beta-HSD2 activity, besides F and E, their tetrahydro- (THF, THE) as well allo-tetrahydro- (allo-THF, allo-THE)
Anil Mongia et al.
The Journal of clinical endocrinology and metabolism, 97(10), 3622-3629 (2012-08-09)
The mineralocorticoid receptor is protected from excess of glucocorticoids by conversion of active cortisol to inactive cortisone by enzyme 11β-hydroxysteroid dehydrogenase type 2 present in the kidney. The metabolites of cortisol and cortisone are excreted in the urine as tetrahydrocortisol
P W Raven et al.
Endocrine research, 22(4), 811-815 (1996-11-01)
The increased ratio of 5 alpha to 5 beta reduced steroids associated with apparent mineralocorticoid excess (AME) may be a necessary consequence of altered 11 beta-hydroxysteroid dehydrogenase (11-HSD) activity. In order to test this hypothesis we have compared changes in
J Müller-Berghaus et al.
Acta paediatrica (Oslo, Norway : 1992), 85(1), 111-113 (1996-01-01)
We report the case of a 16-month-old boy who presented with chronic vomiting, failure to thrive, arterial hypertension and medullary nephrocalcinosis. Laboratory results revealed hypokalaemia, metabolic alkalosis, increased urinary potassium excretion and a hyporeninaemic hypoaldosteronism. Chromatographic determination of urinary steroid
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