P2116
吡非尼酮
≥97% (HPLC), powder, antifibrotic agent
别名:
5-甲基-1-苯基-2-(1H)-吡啶酮
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关于此项目
经验公式（希尔记法）:
C12H11NO
化学文摘社编号:
分子量:
185.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
吡非尼酮, ≥97% (HPLC)
SMILES string
O=C(C=CC(C)=C1)N1C2=CC=CC=C2
InChI key
ISWRGOKTTBVCFA-UHFFFAOYSA-N
InChI
1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
assay
≥97% (HPLC)
form
powder
solubility
H2O: >10 mg/mL at 60 °C (warming for 30 minutes)
DMSO: >20 mg/mL
originator
Shionogi
Quality Level
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相关类别
Application
吡非尼酮用于：
- 作为兔的术后滴眼剂，分析其抗纤维化作用，改进青光眼滤过手术
- 作为抗瘢痕形成剂，检查其是否影响兔植入青光眼引流装置（GDD）后的异物反应
- 在人眼眶成纤维细胞（hOF）原代培养物中测试其抗纤维化潜力
- 作为肿瘤坏死因子（TNFα）抑制剂，研究其在缺氧中的作用
Biochem/physiol Actions
吡非尼酮可抑制胶原生成和成纤维细胞增殖。在多种肺纤维化动物模型和临床试验中显示出抗纤维化和抗炎属性。
吡非尼酮用于治疗特发性肺纤维化（IPF）。有助于减少肺功能下降引起的衰弱，延长无进展生存期。吡非尼酮可抑制人Tenon′s 囊成纤维细胞胶原蛋白的增殖和收缩。
抑制胶原生成和成纤维细胞增殖。
General description
吡非尼酮（5-甲基-1-苯基-2-[1H]-吡啶酮）是合成的吡啶 衍生物。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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