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经验公式(希尔记法):
C16H13NO3
化学文摘社编号:
分子量:
267.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PD 98,059, solid
SMILES string
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI key
QFWCYNPOPKQOKV-UHFFFAOYSA-N
form
solid
color
yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
Gene Information
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Application
PD 98,059已用于:
- 生长培养基,作为有丝分裂原活化蛋白(MAP)激酶抑制剂,以研究与D1样受体作用有关的次级信使
- 无钙RPMI(罗斯威尔公园纪念研究所)-1640培养基,结合囊性纤维化跨膜电导调节剂(CFTR)敲低,研究其对人表皮角质形成细胞系炎症、增殖和分化的影响
- 细胞迁移测定培养基
Biochem/physiol Actions
PD 98,059是一种类黄酮,同时是促分裂原活化蛋白激酶激酶(MAPKK)的特异性抑制剂。在小鼠体内,PD 98,059有助于阻断酵母聚糖刺激的器官功能障碍综合征和非败血性休克。目前确知它可抑制体外肥大。PD 98,059还诱导间充质基质细胞中的软骨形成。
Legal Information
经Warner Lambert公司许可出售。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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