P266
Phorbol 12-phenylacetate 13-acetate 20-homovanillate
solid
别名:
PPAHV
表单
solid
颜色
white
溶解性
DMSO: soluble
H2O: insoluble
SMILES字符串
COc1cc(CC(=O)OCC2=CC3C4C(C)(C)[C@]4(OC(C)=O)[C@H](OC(=O)Cc5ccccc5)[C@@H](C)[C@]3(O)C6C=C(C)C(=O)[C@@]6(O)C2)ccc1O
InChI
1S/C39H44O11/c1-21-14-30-37(45,34(21)44)19-26(20-48-31(42)18-25-12-13-28(41)29(16-25)47-6)15-27-33-36(4,5)39(33,50-23(3)40)35(22(2)38(27,30)46)49-32(43)17-24-10-8-7-9-11-24/h7-16,22,27,30,33,35,41,45-46H,17-20H2,1-6H3/t22-,27+,30-,33-,35-,37-,38-,39-/m1/s1
InChI key
OGRGWTXWAZBJKF-JXWJAAHMSA-N
生化/生理作用
Vanilloid receptor agonist.
法律信息
Sold in France, Germany, Great Britain and Switzerland under license, restricted to research use only, from Procyon Pharmaceuticals, Inc.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J S Shin et al.
Neuroscience letters, 299(1-2), 135-139 (2001-02-13)
Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property. But, the pharmacological profile of VR1 to various CAP analogs is not known. The
L Liu et al.
Neuroscience, 84(2), 569-581 (1998-04-16)
Capsaicin, the vanilloid responsible for the pungent taste of hot peppers, binds to receptors found primarily in polymodal nociceptors. Capsaicin initially stimulates polymodal nociceptors and subsequently inhibits them from responding to a variety of stimuli. This property makes it useful
A Szallasi et al.
European journal of pharmacology, 299(1-3), 221-228 (1996-03-28)
Capsaicin binds to a specific recognition site, referred to as the vanilloid receptor, which it shares with the natural, ultrapotent agonist resiniferatoxin and with the competitive antagonist capsazepine. Upon binding to its receptor, capsaicin opens a cation channel leading to
G Appendino et al.
Journal of medicinal chemistry, 39(16), 3123-3131 (1996-08-02)
A number of phorboid 20-homovanillates were prepared by condensation of phorbol 12,13-diesters and 12-dehydrophorbol 13-esters with Mem-homovanillic acid followed by removal of the protecting group with SnCl4 in THF. These compounds were evaluated for their ability to inhibit [3H]resiniferatoxin (RTX)
Dominic P Geraghty et al.
British journal of pharmacology, 137(6), 919-927 (2002-11-02)
1. Activation of vanilloid receptors on sensory nerve terminals in the commissural nucleus of the solitary tract (cNTS) of rats with capsaicin, produces respiratory slowing. In this study, we used microinjection techniques employing pungent and non-pungent vanilloids to further characterize
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