P2980
Pertussis toxin
from Bordetella pertussis, buffered aqueous glycerol solution, protein endotoxin
别名:
IAP, PTX, 百日咳杆菌属, 组胺敏化因子, 胰岛活化蛋白
Product Name
百日咳毒素 来源于百日咳杆菌, buffered aqueous glycerol solution
描述
aseptically packaged
质量水平
表单
buffered aqueous glycerol solution
运输
dry ice
储存温度
−20°C
SMILES字符串
O(C)C(=O)CCCCCCCCCCCCCCCCCCCCCCCC
InChI
1S/C26H52O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28-2/h3-25H2,1-2H3
InChI key
WOPKHAQDUMDJIY-UHFFFAOYSA-N
基因信息
Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408)
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一般描述
Pertussis (Pertussis) toxin (PTX) is a protein isolated from the bacterium Bordatella (Bordatella) coccobaccillus. The toxin is excreted in a non-active state. When the B oligomer of the bacterium, Bordatella coccobacillus, comes in contact with the cell membrane, an S1 subunit of its A protomer is activated. This activation may be mediated by glutathione and/or ATP.
应用
由百日咳博德特氏菌释放的无活性毒素形式。
该毒素是以无活性形式由百日咳博德特氏菌释放的。当百日咳毒素B寡聚物结合到细胞膜上时，其A原聚体的S1亚基会被激活，这可能是通过谷胱甘肽和ATP的作用而实现的。 在体外激活百日咳毒素的实验方法是由Kaslow等提供的。
Pertussis toxin from Bordetella pertussis has been used: to enhance cardiac myosin immunization of rats to induce myocarditis; to break down the blood–brain barrier in the Cuprizone and cuprizone/MOG-EAE model; as an inhibitor of Gαi signaling
生化/生理作用
百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。
百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。 这可防止G蛋白异源三聚体与受体的相互作用，从而阻止其偶联和激活。 由于Gα亚基仍处于与GDP结合的非活性状态，因此它们无法使腺苷酸环化酶失活或打开K+通道。
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
外形
Aseptically filled solution in 50% glycerol, containing 50 mM TRIS, 10 mM glycine, 0.5 M NaCl, pH 7.5
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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