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Merck
CN

P3293

Sigma-Aldrich

Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide

≥95% (HPLC)

别名:

F-8-F-NH2

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关于此项目

经验公式（希尔记法）:
C54H76N14O10
化学文摘社编号:
99566-27-5
分子量:
1081.27
MDL编号:
MFCD00076704
UNSPSC代码:
12352200
PubChem化学物质编号:
24897882

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方案

≥95% (HPLC)

应用

cell analysis

储存温度

−20°C

SMILES字符串

CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

InChI

1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1

InChI key

HWYCFZUSOBOBIN-AQJXLSMYSA-N

基因信息

rat ... Npffr1(64107)

生化/生理作用

Attenuates analgesic effects of morphine

其他说明

Endogenous peptide found in periaqueductal grey and in dorsal spinal cord

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
036H01121
016H04851
052H01541
036H0112
036H01122

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Flavie Kersanté et al.
Neurochemistry international, 56(6-7), 768-773 (2010-03-10)
The Neuropeptide FF (NPFF) system is known to modulate the effects of opioids in vivo and in vitro. In the present study, we have investigated the effect of NPFF agonists on the coupling of the Mu-opioid (MOP) receptor to G-proteins
Jessica V Mankus et al.
Future medicinal chemistry, 4(9), 1085-1092 (2012-06-20)
Neuropeptide FF (NPFF) was first isolated from the bovine brain in 1985 and is linked with a variety of biological activities. NPFF, which belongs to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2). These
Quan Fang et al.
Protein and peptide letters, 18(4), 403-409 (2010-12-03)
Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in the control of pain and analgesia through interactions with the opioid system. However, very few studies examined the effect of supraspinal NPFF
Catherine Mollereau et al.
Pharmacological reports : PR, 63(4), 1061-1065 (2011-10-18)
This study investigated the presence of neuropeptide FF (NPFF) receptors on F-11 cells, a hybridoma derived from rat dorsal root ganglia (DRG) and mouse neuroblastoma. Binding experiments revealed a low density (4 fmol/mg) of high affinity (0.5 nM) [(3)H]-EYF binding
Jolanta H Kotlinska et al.
Peptides, 36(1), 17-22 (2012-05-15)
NPFF precursor, pro-NPFF(A) contains three known bioactive sequences: NPFF (FLFQPQRF-NH(2)), neuropeptide AF (NPAF; AGEGLSSPFWSLAAPQRF-NH(2)) and neuropeptide SF (NPSF; SLAAPQRF-NH(2)). The key-feature of these fragments is their common PQRF-amidated sequence at their C termini. Here, we evaluated the biological activity of
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