P3737
Monoclonal Anti-p63 antibody produced in mouse
~2 mg/mL, clone 4A4, purified immunoglobulin, buffered aqueous solution
别名:
Anti-B(p51A), Anti-B(p51B), Anti-EEC3, Anti-KET, Anti-TP63
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4A4, monoclonal
表单
buffered aqueous solution
种属反应性
mouse, rat, human
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using whole extract of cultured human keratinocyte HaCaT cells
同位素/亚型
IgG2a
运输
dry ice
储存温度
−20°C
基因信息
human ... TP63(8626)
mouse ... Trp63(22061)
rat ... Tp73l(246334)
一般描述
(P63) is a homologue of the (p53) family and encodes protein having similar amino acid sequence to that of( p53) transactivation domains, DNA binding domains, and oligomerization domains . It is highly expressed in basal or progenitor layers of epithelial tissues . Monoclonal anti-(p63) antibody can be used to study the molecular mechanisms by which (p63) can utilize dominant-negative and gain-of-function mutations involved in development. It can also be used in indirect ELISA and microarray. Mouse monoclonal anti-(p63) antibody reacts specifically with an epitope present in amino acids 1-205 of mouse Np63 isoform. It also reacts with (p63) in rats and humans.
免疫原
recombinant N-terminal portion (amino acids 1-205) of mouse ΔNp63 isoform.
应用
Monoclonal anti-(p63) antibody can be used in immunoblotting, immunocytochemistry and immunohistochemistry. It may also be used for immunoprecipitation and western blot.
法律信息
This product is licensed for RESEARCH USE ONLY under U.S. Patents Nos. 6,946,256 and 7,030,227 owned by Harvard College. Other uses of the Sigma product, for example in diagnostics or therapeutics, are outside the scope of the license and are not authorized. For products licensed for diagnostic use, consult AsymmetRx, Inc. by telephone at 203-228-0209 or by email at pmckeon@asymmetrix.com
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The p53 family: same response, different signals?
1. Chen, X
Molecular Medicine, 2, 387-392 (1999)
K M Liefer et al.
Cancer research, 60(15), 4016-4020 (2000-08-17)
In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B
Tzu-Wei Wang et al.
Artificial organs, 30(3), 141-149 (2006-02-17)
In order to develop an adequate scaffold for skin tissue engineering, a bilayered gelatin-chondroitin 6 sulfate-hyaluronic acid membrane with a different pore size on either side was prepared. A rete ridges-like topographic microporous structure, which provided the paracrine crosstalk in
Andreas Birbach et al.
Genesis (New York, N.Y. : 2000), 47(11), 757-764 (2009-10-16)
Tissue-specific transgene expression in the prostate epithelium has previously been achieved using short prostate-specific promoters, rendering transgenic mouse lines susceptible to integration site-dependent effects. Here we demonstrate the applicability of bacterial artificial chromosome (BAC) technology to transgene expression in the
p63 and p73: old members of a new family.
M C Marin et al.
Biochimica et biophysica acta, 1470(3), M93-M100 (2000-05-09)
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