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Merck
CN

P4510

Sigma-Aldrich

聚-ε-Cbz-L-赖氨酸

mol wt 500-4,000

别名:

N6-[(phenylmethoxy)carbonyl]-L-lysine homopolymer

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关于此项目

CAS Number:
25931-47-9
MDL编号:
MFCD00166378
UNSPSC代码:
12352209
NACRES:
NA.26

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表单

powder

质量水平

200

分子量

500-4,000

颜色

white

储存温度

−20°C

SMILES字符串

[N+H3][C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)[O-]

InChI

1S/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m0/s1

InChI key

CKGCFBNYQJDIGS-LBPRGKRZSA-N

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相关类别

应用


  • 聚乙烯亚胺包被微球的转染技术。：该研究探讨了利用聚乙亚胺包被微球中的聚-e-苄氧羰基-L-赖氨酸来增强细胞转染的方法，结果表明这种方法提高了效率，并有可能应用于基因治疗（Manuel WS et al., 2001）。

  • 由表面结合聚乙烯亚胺的生物可降解聚合物材料介导的细胞转染。：研究重点是用于细胞转染的生物可降解聚合物材料，包括聚乙二醇-苄氧羰基-L-赖氨酸对聚，强调了它们的生物可降解性和传递遗传物质的有效性（Zheng J et al., 2000）。

  • 用聚（乳酸-共聚乙二醇）和聚（ε-CBZ-L-赖氨酸）的混合物生产表面带有氨基的微球并用于封装。：这篇论文讨论了利用聚乙二醇-苄氧羰基-L-赖氨酸的混合物制造带有表面氨基的微球，然后将其用于封装活性剂，并指出了其在给药系统中的应用（Zheng J et al., 1999）。

  • 对聚（L-乳酸）材料进行改性，使其能与生物聚合物共价结合：应用于在附有胶原蛋白的泡沫中进行高密度三维细胞培养。：该研究探讨了用聚乙二醇-苄氧羰基-L-赖氨酸对聚（L-乳酸）材料进行改性，使其与生物聚合物共价结合，从而促进高密度三维细胞培养的应用（Zheng J et al., 1998）。

分析说明

电喷雾质谱法分子量

其他说明

如需关于聚氨基酸的额外技术信息，请访问聚氨基酸FAQ资源。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCL9103
SLCN7105
SLCK5713
SLBW2595
SLBR9159V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Product P4510, Poly-ε-Cbz-L-lysine has a Cbz (carbobenzoxy) protecting group on the ε-amino group of each lysine. What are the structures of the α-amino-terminus and the carboxy-terminus, and are the end groups detectable by NMR?

    The end groups are free amino (-NH2) and carboxyl (-COOH). Because this a polydisperse material, it would be difficult to detect distinctive end groups via NMR.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

W S Manuel et al.
Journal of drug targeting, 9(1), 15-22 (2001-05-30)
Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing
Chimdiya Onwukwe et al.
Bioconjugate chemistry, 29(7), 2436-2447 (2018-07-03)
Bleeding from traumatic injury is the leading cause of death for young people across the world, but interventions are lacking. While many agents have shown promise in small animal models, translating the work to large animal models has been exceptionally
J Zheng et al.
Biotechnology progress, 15(4), 763-767 (1999-08-12)
Microspheres were formed from blends of the biodegradable polymer poly(DL-lactic-co-glycolic acid) (PLGA) together with poly(epsilon-CBZ-L-lysine) (PCBZL) by a double-emulsification/solvent evaporation technique. The size of the microspheres formed by this method was dependent both on the total concentration of the polymers
Qian Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 303, 117-129 (2019-04-27)
Brain metastases present mostly multifocal, infiltrative and co-opting growth with the blood-brain barrier (BBB) remaining intact. The BBB, as the barrier of drug delivery to such lesions, is the major cause of the failure of systemic drug therapy and needs
J Zheng et al.
Biotechnology progress, 16(2), 254-257 (2000-04-08)
Poly(epsilon-CBZ-L-lysine) can be mixed with biodegradable polymers such as poly(D,L-lactic-co-glycolic acid) or poly(L-lactic acid) and formed into films, foams, or microspheres. Surface amino groups may then be deprotected with acid or lithium/liquid ammonia. The amino groups serve as a method

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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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