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CN

P6273

Sigma-Aldrich

2-丙基戊酸

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别名:
丙戊酸
线性分子式:
(CH3CH2CH2)2CHCO2H
CAS号:
分子量:
144.21
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

质量水平

折射率

n20/D 1.425 (lit.)

bp

220 °C (lit.)

溶解性

H2O: slightly soluble
alcohol: soluble

密度

0.9 g/mL at 25 °C (lit.)

lipid type

saturated FAs

SMILES string

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

InChI key

NIJJYAXOARWZEE-UHFFFAOYSA-N

Gene Information

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PHR10618.14439V0033000
2-Propylpentanoic acid

Sigma-Aldrich

P6273

2-丙基戊酸

Valproic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1061

丙戊酸

2-Propylvaleric acid for synthesis

Sigma-Aldrich

8.14439

2-Propylvaleric acid

Valproic acid European Pharmacopoeia (EP) Reference Standard

V0033000

丙戊酸

bp

220 °C (lit.)

bp

220 °C (lit.)

bp

220 °C/1013 hPa

bp

220 °C (lit.)

solubility

H2O: slightly soluble, alcohol: soluble

solubility

-

solubility

-

solubility

-

density

0.9 g/mL at 25 °C (lit.)

density

0.9 g/mL at 25 °C (lit.)

density

0.905 g/cm3 at 20 °C

density

0.9 g/mL at 25 °C (lit.)

lipid type

saturated FAs

lipid type

-

lipid type

-

lipid type

-

Gene Information

human ... ALDH5A1(7915), CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)

Gene Information

human ... ALDH5A1(7915)

Gene Information

-

Gene Information

human ... ALDH5A1(7915)

应用

2-丙基戊酸作为补充剂,用于小鼠胚胎成纤维细胞条件培养基(MEF-CM),培养细胞。

生化/生理作用

2-丙基戊酸是短链脂肪酸,或能抑制组蛋白去乙酰化酶的作用。可促进肿瘤细胞毒性,增加对辐射的敏感性。2-丙基戊酸可提高大脑中 γ-氨基丁酸水平。 存在过量2-丙基戊酸,则可观察到中枢神经系统作用减弱。它通过阻断电压依赖性钠通道,增强 γ-氨基丁酸(GABA)的抑制作用。
抗惊厥药,同时还具有双相障碍症情绪稳定剂的功效

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

231.8 °F - closed cup

闪点(°C)

111 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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