P6490
PGP-4008
别名:
N-(1-Benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide
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关于此项目
经验公式（希尔记法）:
C26H23N3O
化学文摘社编号:
分子量:
393.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
InChI key
HVIAKQBMYMKWII-UHFFFAOYSA-N
SMILES string
O=C(Cc1ccccc1)Nc2c3CCN(Cc4ccccc4)c3nc5ccccc25
InChI
1S/C26H23N3O/c30-24(17-19-9-3-1-4-10-19)28-25-21-13-7-8-14-23(21)27-26-22(25)15-16-29(26)18-20-11-5-2-6-12-20/h1-14H,15-18H2,(H,27,28,30)
assay
≥90% (TLC)
form
powder
storage temp.
−20°C
Quality Level
Application
Selectively inhibits P-glycoprotein.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
C D Smith et al.
Oncology research, 12(5), 219-229 (2001-06-22)
Tumor cells often develop drug resistance through overexpression of membrane transport proteins that effectively efflux anticancer agents. The pharmacologies of the two best-studied transporters, P-glycoprotein (Pgp) and MRP1, are partially overlapping but distinct. To improve the therapeutic potential of drug
商品
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
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