P6523
N-丙酰普鲁卡因胺
储存温度
−20°C
SMILES字符串
CCN(CC)CCNC(=O)c1ccc(NC(=O)CC)cc1
InChI
1S/C16H25N3O2/c1-4-15(20)18-14-9-7-13(8-10-14)16(21)17-11-12-19(5-2)6-3/h7-10H,4-6,11-12H2,1-3H3,(H,17,21)(H,18,20)
InChI key
CTHPVGZIOICAFO-UHFFFAOYSA-N
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J Kusowska
Acta poloniae pharmaceutica, 46(1), 90-97 (1989-01-01)
In the recent years a remarkable number of new antiarrhythmic drugs have been introduced, but their side effects limit the application. Procainamide (PA) and N-acetylprocainamide (Acekainide, NAPA) display many undesired side effects, too. It was assumed that N-propionyl-procainamide, having antiarrhythmic
[A new anti-arrhythmia drug. I. Study of the anti-arrhythmia effects of a new N-acyl derivative of procainamide in rabbits].
J Kusowska
Acta poloniae pharmaceutica, 45(4), 346-350 (1988-01-01)
Yoo-Seong Jeong et al.
Pharmaceutics, 11(3) (2019-03-09)
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despite an abundance of in vitro and in vivo
J Kusowska et al.
Acta poloniae pharmaceutica, 46(2), 187-194 (1989-01-01)
Procainamide (PA) often applied in cases of ventricular arrhythmias causes numerous cardiac and extracardiac undesirable symptoms. Its active metabolite, N-acetylprocainamide (NAPA; Acecainide) is known to affect less noxiously the ventriculo-atrial conduction and the intraventricular++ conduction, and it does not impair
Anusha Balla et al.
Pharmaceutics, 10(2) (2018-03-31)
A simple, sensitive, and reliable reversed-phase, Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled with a Diode Array Detector (DAD) method for the simultaneous determination of Procainamide (PA) and its major metabolite, N-acetylprocainamide (NAPA), in rat plasma was developed and validated. A simple
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