P6537
β-Acetyl-γ-O-octadecyl-L-α-phosphatidylcholine
≥98%
别名:
1-O-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine, PAF(C18)
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关于此项目
经验公式（希尔记法）:
C28H58NO7P
化学文摘社编号:
分子量:
551.74
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C28H57NO8P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-28(31)34-24-27(37-26(2)30)25-36-38(32,33)35-23-22-29(3,4)5/h27H,6-25H2,1-5H3,(H,32,33)
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCCCC)=O
InChI key
WRNJZNCFXCBLTH-UHFFFAOYSA-N
assay
≥98%
solubility
chloroform: 10 mg/mL, aqueous base: decomposes
storage temp.
−20°C
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Biochem/physiol Actions
18-carbon analog of platelet activating factor (PAF); ligand for G protein-coupled PAF receptor. It is less potent than PAF C-16 for inducing platelet aggregation, hypotension, bronchosconstriction and chemotaxis, but more potent than PAF C-16 for inducing human neutrophil lysosomal secretion.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
E J Carolan et al.
Journal of immunology (Baltimore, Md. : 1950), 145(8), 2561-2565 (1990-10-15)
Multiple molecular species of platelet activating factor (PAF) are produced as a result of inflammatory processes. PAF-induced neutrophil migration across endothelium is intrinsic to inflammatory responses. We therefore compared the ability of three naturally occurring PAF species (C16:0, C18:0, and
Kimberly D Dyer et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 6327-6334 (2010-04-28)
Platelet-activating factor (PAF [1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine]) is a phospholipid mediator released from activated macrophages, mast cells, and basophils that promotes pathophysiologic inflammation. Eosinophil responses to PAF are complex and incompletely elucidated. We show in this article that PAF and its 2-deacetylated metabolite
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