P7674
噻嘧啶 (+)-酒石酸盐
别名:
1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine
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关于此项目
经验公式（希尔记法）:
C11H14N2S · C4H6O6
化学文摘社编号:
分子量:
356.39
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
251-501-8
MDL number:
InChI key
VWRCYAZJKNPEQR-NIEARKAZSA-N
InChI
1S/C11H14N2S.C4H6O6/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10;5-1(3(7)8)2(6)4(9)10/h2,4-6,9H,3,7-8H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/b6-5+;/t;1-,2-/m.1/s1
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CCCN=C1\C=C\c2cccs2
solubility
H2O: 4.0 mL, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL )
antibiotic activity spectrum
parasites
mode of action
enzyme | inhibits
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Application
Pyrantel is used to study neuronal nicotinic receptors and has been is used to treat parasiticinfections in livestock. Pyrantel tartrate salt is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs).
Biochem/physiol Actions
Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. Cholinesterase inhibitor.
Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. This is a cholinesterase inhibitor. It causes spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors.
Other Notes
Keep container tightly closed in a dry and well-ventilated place
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
M Stankiewicz et al.
The Journal of parasitology, 76(3), 383-388 (1990-06-01)
Cross-bred 3- and 8-wk-old pigs were used to test whether drug-abbreviated infections with Ascaris suum can stimulate acquired resistance to challenge. During the immunization period, both age groups of animals were infected with increasing numbers of A. suum eggs (500
G A Conder et al.
The Journal of parasitology, 77(4), 621-623 (1991-08-01)
Haemonchus contortus- and Trichostrongylus colubriformis-infected jirds (Meriones unguiculatus) are useful for anthelmintic studies. With concurrent infections of these parasites established in the jird, questions of not only anthelmintic activity, but to some extent spectrum, could be assessed in a single
C Chartier et al.
Veterinary parasitology, 59(1), 69-73 (1995-08-01)
The efficacy of pyrantel tartrate was evaluated in goats against induced infections with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis. All the strains were of sheep origin and tested for susceptibility to pyrantel tartrate in sheep at the standard dose
L L Southern et al.
Journal of animal science, 67(3), 628-634 (1989-03-01)
An experiment was conducted with 96 weanling pigs (avg initial wt 18.5 kg) divided into six treatment with two replicates of eight pigs each. Pigs in Treatments 1, 2 and 3 were penned in outside pens with dirt lots that
M Stankiewicz et al.
International journal for parasitology, 20(1), 77-81 (1990-02-01)
Crossbred young pigs were used to test whether abbreviated infections with eggs of Ascaris suum can stimulate the acquisition of resistance to challenge. Weanling pigs from an Ascaris-free colony were kept free of A. suum until they were divided into
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