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Merck
CN

P7762

聚L -精氨酸 盐酸盐

mol wt 15,000-70,000

别名:

L-Arginine homopolymer hydrochloride

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关于此项目

化学文摘社编号:
26982-20-7
NACRES:
NA.26
PubChem Substance ID:
24898874
UNSPSC Code:
12352209
MDL number:
MFCD00166393

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产品名称

聚L -精氨酸 盐酸盐, mol wt 15,000-70,000

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

form

powder

mol wt

15,000-70,000

color

white to off-white

application(s)

cell analysis

storage temp.

−20°C

Quality Level

200

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Analysis Note

分子量基于前体聚-L-鸟氨酸的粘度。 也由MALLS所测定的。
含有3%或更低的鸟氨酸残基。

Application

聚-L-精氨酸盐酸盐已用于：
  • 与isRNA9.2s形成复合物刺激中性粒细胞
  • 在核糖体RNA转染人单核细胞THP-1中使用
  • 包裹海藻酸微囊球

General description

聚-L-精氨酸盐酸盐(PLA)是一种同型多聚氨基酸。聚L精氨酸盐酸盐相比聚-L-赖氨酸更能增强膜通透性。它可用作药物载体、神经保护剂及用于抗癌免疫制剂。PLA与多肽疫苗混用可促进抗原呈递细胞(APC)介导的T细胞生成并激发免疫兴奋作用。

Other Notes

有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000511897
0000511897
0000511896
0000511896
0000439952

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Neutrophils express distinct RNA receptors in a non-canonical way
Berger M, et al.
The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)
RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells
Nishibayashi R, et al.
PLoS ONE, 10(6), e0129806-e0129806 (2015)
Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells
Bhujbal SV, et al.
Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208 (2014)
Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens
Mattner F, et al.
Cancer Research, 62(5), 1477-1480 (2002)
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
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