P8390
木防己苦毒宁
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关于此项目
经验公式（希尔记法）:
C15H16O6
化学文摘社编号:
分子量:
292.28
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.77
表单
powder
SMILES字符串
[H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
InChI
1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
InChI key
PIMZUZSSNYHVCU-KBLUICEQSA-N
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一般描述
Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.
应用
Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.
生化/生理作用
GABAA 受体拮抗剂；与受体连接的Cl−通道结合。
Picrotoxinin acts as a potent convulsant.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
其他说明
Active component of picrotoxin
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
R Martín-Ruiz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(24), 9856-9866 (2001-12-12)
We examined the in vivo effects of the hallucinogen 4-iodo-2,5-dimethoxyamphetamine (DOI). DOI suppressed the firing rate of 7 of 12 dorsal raphe (DR) serotonergic (5-HT) neurons and partially inhibited the rest (ED(50) = 20 microg/kg, i.v.), an effect reversed by
Jane E Carland et al.
European journal of pharmacology, 580(1-2), 27-35 (2007-11-23)
The relative impact on picrotoxinin activity of residues at the intracellular (2' and 6' residues) and extracellular (15' and 17' residues) ends of the second transmembrane (M2) domain of the human gamma-aminobutyric acid-C (GABA(C)) rho1 receptor was investigated. A series
J Baufreton et al.
Journal of neurophysiology, 86(1), 75-85 (2001-06-30)
The subthalamic nucleus (STN) influences the output of the basal ganglia, thereby interfering with motor behavior. The main inputs to the STN are GABAergic. We characterized the GABA(A) receptors expressed in the STN and investigated the response of subthalamic neurons
Y Eguchi et al.
Insect molecular biology, 15(6), 773-783 (2007-01-05)
Ligand-gated chloride channels (LGICs) are important targets for insecticides and parasiticides. Genes encoding subunits of two LGICs, a glutamate-gated chloride channel (MdGluCl-alpha) and a gamma-aminobutyric acid (GABA)-gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). These genes were
Herbal products and GABA receptors
Johnston GAR
Encyclopedia of Neuroscience, 4, 1095-1101 (2009)
商品
DISCOVER Bioactive Small Molecules for Neuroscience
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