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Merck
CN

P8390

木防己苦毒宁

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经验公式(希尔记法):
C15H16O6
化学文摘社编号:
分子量:
292.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI

1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1

SMILES string

[H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C

InChI key

PIMZUZSSNYHVCU-KBLUICEQSA-N

form

powder

Quality Level

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General description

Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.

Application

Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.

Biochem/physiol Actions

GABAA 受体拮抗剂;与受体连接的Cl通道结合。
Picrotoxinin acts as a potent convulsant.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Active component of picrotoxin

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Xiu-Lian Ju et al.
Chemosphere, 69(6), 864-871 (2007-08-07)
A number of widely diverse compounds that show inhibitory activities at the picrotoxinin binding sites in housefly and rat GABA receptors were investigated by using the distance comparison technique (DISCOtech) and comparative molecular field analysis (CoMFA) methods to explore the
Allosteric ligands and their binding sites define $\gamma$-aminobutyric acid (GABA) type A receptor subtypes
Advances in Pharmacology, 73, 167-202 (2015)
Y Eguchi et al.
Insect molecular biology, 15(6), 773-783 (2007-01-05)
Ligand-gated chloride channels (LGICs) are important targets for insecticides and parasiticides. Genes encoding subunits of two LGICs, a glutamate-gated chloride channel (MdGluCl-alpha) and a gamma-aminobutyric acid (GABA)-gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). These genes were
Herbal products and GABA receptors
Johnston GAR
Encyclopedia of Neuroscience, 4, 1095-1101 (2009)
Shelley H Huang et al.
European journal of pharmacology, 494(2-3), 131-138 (2004-06-24)
Ginkgolides A, B, and C are diterpene trilactones and active constituents of the 50:1 Ginkgo biloba leaf extract widely used in the symptomatic treatment of mild to moderate dementia. Using the two-electrode voltage clamp methodology, these ginkgolides were found to

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