P8390
木防己苦毒宁
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关于此项目
经验公式（希尔记法）:
C15H16O6
化学文摘社编号:
分子量:
292.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
SMILES string
[H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
InChI key
PIMZUZSSNYHVCU-KBLUICEQSA-N
form
powder
Quality Level
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General description
Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.
Application
Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.
Biochem/physiol Actions
GABAA 受体拮抗剂；与受体连接的Cl−通道结合。
Picrotoxinin acts as a potent convulsant.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Active component of picrotoxin
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
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Xiu-Lian Ju et al.
Chemosphere, 69(6), 864-871 (2007-08-07)
A number of widely diverse compounds that show inhibitory activities at the picrotoxinin binding sites in housefly and rat GABA receptors were investigated by using the distance comparison technique (DISCOtech) and comparative molecular field analysis (CoMFA) methods to explore the
Allosteric ligands and their binding sites define $\gamma$-aminobutyric acid (GABA) type A receptor subtypes
Advances in Pharmacology, 73, 167-202 (2015)
Y Eguchi et al.
Insect molecular biology, 15(6), 773-783 (2007-01-05)
Ligand-gated chloride channels (LGICs) are important targets for insecticides and parasiticides. Genes encoding subunits of two LGICs, a glutamate-gated chloride channel (MdGluCl-alpha) and a gamma-aminobutyric acid (GABA)-gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). These genes were
Herbal products and GABA receptors
Johnston GAR
Encyclopedia of Neuroscience, 4, 1095-1101 (2009)
Shelley H Huang et al.
European journal of pharmacology, 494(2-3), 131-138 (2004-06-24)
Ginkgolides A, B, and C are diterpene trilactones and active constituents of the 50:1 Ginkgo biloba leaf extract widely used in the symptomatic treatment of mild to moderate dementia. Using the two-electrode voltage clamp methodology, these ginkgolides were found to
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DISCOVER Bioactive Small Molecules for Neuroscience
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