P9386
聚-L-组氨酸
mol wt 5,000-25,000
别名:
L-Histidine homopolymer
产品名称
聚-L-组氨酸, mol wt 5,000-25,000
SMILES string
[N+H3][C@@H](Cc1[nH]cnc1)C(=O)[O-]
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
form
powder or solid
mol wt
5,000-25,000
color
white to light yellow
application(s)
cell analysis
storage temp.
−20°C
Quality Level
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Analysis Note
分子量 (MALLS)。
Application
聚L-组氨酸已用于：
- 作为聚阳离子分散多壁碳纳米管(MWCNT)
- 作为多离子化合物研究其破坏细胞外包膜病毒膜的能力
- 通过在细胞水平上和在体内的抗朊毒体(prion)分析，进行其抗朊毒体活性筛选
Biochem/physiol Actions
聚L-组氨酸(Phis)共聚物具有生物相容性、pH响应性和较低的毒性。它具有逃逸内溶酶体的功能。聚L组氨酸与聚乙二醇−聚(d,l-丙交酯) (PEG-PLA)的共聚物可有效递送阿霉素。pH敏感性聚l-组氨酸共聚物胶束可在酸性微环境中递送抗癌药物。
General description
聚-L-组氨酸是一种两性化合物。结构中的咪唑环可进行质子化−去质子化反应。
Other Notes
有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Poly (l-histidine) based copolymers: effect of the chemically substituted l-histidine on the physio-chemical properties of the micelles and in vivo biodistribution
Zhang X, et al.
Colloids and Surfaces. B, Biointerfaces, 140(5), 176-184 (2016)
Shoichiro Asayama et al.
Bioconjugate chemistry, 23(7), 1437-1442 (2012-06-12)
Poly(L-histidine) (PLH) with dimethylimidazole groups has been synthesized as a pH-sensitive polypeptide to control the stability of its small interfering RNA (siRNA) polyion complexes for RNA interference (RNAi). The resulting methylated PLH (PLH-Me) was water-soluble despite deprotonation of the imidazole
Pablo R Dalmasso et al.
Biosensors & bioelectronics, 39(1), 76-81 (2012-07-17)
We report for the first time the development of a sensitive and selective glucose biosensor based on the self-assembling of multiwall carbon nanotubes (MWCNTs) dispersed in polyhistidine (Polyhis) and glucose oxidase (GOx) on glassy carbon electrodes (GCE). The supramolecular architecture
Hongbo Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1935-1944 (2012-07-12)
Many laboratories use recombinant UDP-glucuronosyltransferases (UGTs), expressed in baculovirus-infected insect cells, for drug glucuronidation studies. We have infected Sf9 insect cells with increasing amounts of recombinant baculovirus, encoding either UGT1A9 or UGT2B7, and measured both glucuronidation activity and immunodetectable UGT
Yi-Fang Zeng et al.
Biomaterials, 33(36), 9239-9245 (2012-10-03)
Loading of viral vectors in synthetic polymers is a promising strategy for overcoming hurdles associated with viral gene delivery. For enhanced gene expression at a specific site, gene transfer by using hydrogels represents a versatile approach. In this study, adeno-associated
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