PENK
青霉素G 钾盐
95.0 - 102.0%
别名:
苄青霉素 钾盐
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关于此项目
经验公式（希尔记法）:
C16H17KN2O4S
化学文摘社编号:
分子量:
372.48
UNSPSC Code:
51283424
NACRES:
NA.85
PubChem Substance ID:
EC Number:
204-038-0
Beilstein/REAXYS Number:
3832841
MDL number:
产品名称
青霉素G 钾盐, 95.0 - 102.0%
InChI
1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChI key
IYNDLOXRXUOGIU-LQDWTQKMSA-M
SMILES string
[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
assay
95.0 - 102.0%
form
powder
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
Quality Level
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Biochem/physiol Actions
作用机制：青霉素G通过与青霉素结合蛋白(PBP)结合抑制肽聚糖链交联，从而抑制细胞壁合成。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
Application
Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci† and the penicillin-induced lysis of Streptococcus mutans†.
Disclaimer
Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Handle and store under inert gas. Keep in a dry place.Very soluble in water, slightly soluble in ethanol (96%), practically insoluble in methylene chloride
Packaging
1mu,10mu,100mu
T A Kral et al.
Infection and immunity, 46(2), 442-447 (1984-11-01)
Treatment of Streptococcus mutans GS-5 cells with concentrations of penicillin G within a relatively narrow range resulted in substantial lysis. This penicillin-induced lysis was dependent upon cell density and pH of the lysis medium. Other oral streptococci (Streptococcus sobrinus, Streptococcus
P Giesbrecht et al.
Journal of bacteriology, 174(7), 2241-2252 (1992-04-01)
Electron microscopic research into the murosomes of staphylococci has shown that the number of murosomes involved in penicillin-induced death varies depending on the experimental conditions employed. With 0.1 micrograms of penicillin G per ml, only 1 of a total of
Mariagrazia Perilli et al.
Antimicrobial agents and chemotherapy, 57(2), 1047-1049 (2012-11-28)
Two laboratory mutant forms, TEM-149(H240) and TEM-149(H164-H240), of the TEM-149 extended-spectrum β-lactamase enzyme were constructed by site-directed mutagenesis. TEM-149(H240) and TEM-149(H164-H240) were similar in kinetic behavior, except with respect to benzylpenicillin and ceftazidime. Molecular modeling of the two mutant enzymes
Lemierre's syndrome in systemic lupus erythematosus: a report of two cases.
J C Rødgaard et al.
Scandinavian journal of rheumatology, 42(2), 167-168 (2013-01-15)
Eleonor G Lago et al.
Sexually transmitted diseases, 40(2), 85-94 (2013-01-18)
The aim of this study was to investigate clinical features and outcomes of children treated for congenital syphilis (CS). Infants born alive in the public sector of São Lucas Hospital, Porto Alegre, Brazil, 1997 to 2004, whose mothers had syphilis
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