PZ0198
普马司他 盐酸盐
≥95% (HPLC), MMP inhibitor, powder
别名:
(S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride, AG 3340 hydrochloride, AG-3340 hydrochloride, AG3340 hydrochloride
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关于此项目
经验公式（希尔记法）:
C18H21N3O5S2 · HCl
化学文摘社编号:
分子量:
459.97
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
产品名称
普马司他 盐酸盐, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL (clear solution)
storage temp.
room temp
SMILES string
Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
InChI
1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
InChI key
UQGWXXLNXBRNBU-NTISSMGPSA-N
General description
Prinomastat comprises hydroxamic acid group and chelates with zinc ion.PMID 25667046
Application
Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samplesPMID 12225776 and mouse embryo cultures.PMID 12508050 It may be used as a MMP-2 inhibitor in HepG2 cells.PMID 28883413
Biochem/physiol Actions
Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.
Prinomastat is a matrix metalloprotease (MMP) inhibitor.
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable