PZ0348
NI-42
≥98% (HPLC)
别名:
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
CC1=CC2=CC(NS(=O)(C3=CC=C(C#N)C=C3)=O)=CC=C2N(C)C1=O
InChI
1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3
InChI key
BMVCSXFOQPYKKC-UHFFFAOYSA-N
生化/生理作用
NI-42 is a biased potent small molecule inhibitor of the bromodomain of the BRPF (bromodomain and PHD finger-containing) proteins, which are scaffolding proteins that assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family. NI-42 has an IC50 value of of 7.9 nM and is suitable for cellular and in vivo studies.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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