R0281
RNF11 human
recombinant, expressed in E. coli (histidine-tagged), ≥90% (SDS-PAGE), buffered aqueous solution
别名:
CGI-123, MGC51169, RING Finger Protein 11, SID1669
重组
expressed in E. coli (histidine-tagged)
方案
≥90% (SDS-PAGE)
表单
buffered aqueous solution
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... RNF11(26994)
生化/生理作用
RNF11 (RING Finger Protein 11) is a RING E3 ubiquitin ligase with potential to mediate ubiquitination and subsequent proteolysis. RNF11 binds numerous proteins in a variety of cellular pathways, including TGFβ and EGFR signaling. RNF11 expression is elevated in breast and prostate cancer. RNF11 may represent an important target for novel cancer therapies.
外形
Solution in 50 mM Tris, pH 7.5, 150 mM NaCl, 1 mM DTT, and 30% glycerol (w/v).
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Michael K Connor et al.
Oncogene, 23(11), 2089-2095 (2004-03-17)
The identification of novel tumor-associated genes represents an important area of cancer research. To that end, we have discovered a number of genes whose expression is altered in breast tumors. One of these genes has been identified as the ring
Angelika Burger et al.
Neoplasia (New York, N.Y.), 8(8), 689-695 (2006-08-24)
Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways. RING E3 ligases promote the ubiquitination of proteins that are essential to
Michael K Connor et al.
Molecular cancer research : MCR, 3(8), 453-461 (2005-08-27)
Ring finger proteins serve many vital functions within the cell. We have identified RNF11, a novel 154-amino acid ring finger-containing protein, which is elevated in breast cancer. Within its ring finger domain, RNF11 contains an AKT phosphorylation site (T135) that
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