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R0382

倒千里光碱

Name: 倒千里光碱
Brand: SIGMA

≥90% (HPLC), powder, retronecine-type pyrrolizidine alkaloid

别名:

Retrorsin, Senecionan-11,16-Dione, 12,18-Dihydroxy- (9CI), β-Longilobine, 12,18-Dihydroxysenecionan-11,16-dione

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₅NO₆

化学文摘社编号:

480-54-6

分子量:

351.39

UNSPSC Code:

12352200

PubChem Substance ID:

24899338

NACRES:

NA.77

Assay:

≥90% (HPLC)

Quality level:

100

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属性

产品名称

倒千里光碱, ≥90% (HPLC)

Quality Level

100

assay

≥90% (HPLC)

mp

208-211 °C (lit.)

SMILES string

C\C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23

InChI

1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1

InChI key

BCJMNZRQJAVDLD-CQRYIUNCSA-N

说明

Application

Retrorsine has been used:

as a mito-inhibitory pyrrolizidine alkaloid compound to induce necrotic liver injury in rats
to induce hepatocellular injury in rats
to arrest endogenous hepatocyte growth in mice

Biochem/physiol Actions

Retrorsine (RTS) is a retronecine-type pyrrolizidine alkaloid associated with Senecio and Crotalaria species. It belongs to the pyrrolizidine alkaloid family with mito-inhibitory property and elicits hepatotoxicity. It mediates the inactivation of cytochrome P450 3A4. Retrorsine also inhibits replication of fully differentiated hepatocytes.

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pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

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Contribution of mature hepatocytes to small hepatocyte-like progenitor cells in retrorsine-exposed rats with chimeric livers.

Ya-Hui Chen et al.

Hepatology (Baltimore, Md.), 57(3), 1215-1224 (2012-10-20)

The potential lineage relationship between hepatic oval cells, small hepatocyte-like progenitor cells (SHPCs), and hepatocytes in liver regeneration is debated. To test whether mature hepatocytes can give rise to SHPCs, rats with dipeptidyl peptidase IV (DPPIV) chimeric livers, which harbored

HSQC-1,1-ADEQUATE and HSQC-1,n-ADEQUATE: enhanced methods for establishing adjacent and long-range 13C-13C connectivity networks.

Gary E Martin et al.

Journal of natural products, 74(11), 2400-2407 (2011-11-08)

1H-13C GHSQC and GHMBC spectra are irrefutably among the most valuable 2D NMR experiments for the establishment of unknown chemical structures. However, the indeterminate nature of the length of the long-range coupling(s) observed via the (n)J(CH)-optimized delay of the GHMBC

Hepatocyte transplantation and the differentiation fate of host oval cells in acute severe hepatic injury.

Chun-Hsien Yu et al.

Cell transplantation, 19(2), 231-243 (2009-11-13)

Oval cells and hepatocytes rarely proliferate simultaneously. This study aimed to determine the impacts of hepatocyte transplantation on the response and fate of oval cells that are activated to proliferate in acute severe hepatic injury. Retrorsine + D-galactosamine (R+D-gal) treatment

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全球贸易项目编号

货号	GTIN
R0382-500MG	04061833631584
R0382-100MG	04061836693824