R101
雷尼替丁 盐酸盐
H2 histamine receptor antagonist;, solid
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关于此项目
经验公式（希尔记法）:
C13H22N4O3S · HCl
CAS Number:
分子量:
350.86
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
雷尼替丁 盐酸盐, solid
表单
solid
质量水平
颜色
tan
溶解性
H2O: 1.8 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
创始人
GlaxoSmithKline
SMILES字符串
Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI
1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key
GGWBHVILAJZWKJ-CHHCPSLASA-N
基因信息
human ... HRH2(3274)
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应用
盐酸雷尼替丁已被用作开发和验证平行人工膜渗透性试验 (PAMPA) 的参考化合物。
生化/生理作用
H2 组胺受体拮抗剂；抗溃疡剂。
雷尼替丁主要用于治疗非甾体类抗炎药 (NSAID) 引起的胃肠道损害。
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ranitidine
Grant S M, et al.
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P W Bliss et al.
Alimentary pharmacology & therapeutics, 13(12), 1669-1674 (1999-12-14)
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H van der Goot et al.
European journal of medicinal chemistry, 35(1), 5-20 (2000-03-25)
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