R108
Ro 41-0960
solid
别名:
2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
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关于此项目
经验公式（希尔记法）:
C13H8FNO5
化学文摘社编号:
分子量:
277.20
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
储存条件
protect from light
颜色
yellow
溶解性
H2O: slightly soluble <0.7 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL
ethanol: soluble
储存温度
2-8°C
SMILES字符串
Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
InChI
1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
InChI key
RQPAUNZYTYHKHA-UHFFFAOYSA-N
基因信息
human ... COMT(1312)
应用
Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.
生化/生理作用
Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.
特点和优势
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
免责声明
Store tightly sealed at 4 °C, protected from exposure to light.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Mamoun M Alhamadsheh et al.
Science translational medicine, 3(97), 97ra81-97ra81 (2011-08-26)
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Mathias E Jensen et al.
Neurochemistry international, 138, 104772-104772 (2020-05-29)
A solid body of preclinical evidence shows that glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate the effects of substance use disorder related behaviors. The mechanisms underlying these effects remain elusive. In the present study, we hypothesized that GLP-1R activation modulates dopaminetransporter
M H Hassan et al.
Human reproduction (Oxford, England), 26(11), 3008-3018 (2011-09-08)
Uterine leiomyomas (fibroids) are the most common pelvic tumors in women. We assessed the potential therapeutic utility of Ro 41-0960, a synthetic catechol-O-methyl transferase inhibitor (COMTI), in the Eker rat. We randomized uterine fibroid-bearing Eker rats for treatment with Ro
Majorie B M van Duursen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 81(2), 316-324 (2004-07-16)
Phytochemicals are natural dietary constituents of fruits and vegetables. Some of these phytochemicals are known to affect estrogen-metabolizing enzymes. In breast tissue, estradiol can be metabolized to the catechol estrogens 2- and 4-hydroxyestradiol (2-OHE(2) and 4-OHE(2)). Catechol estrogens are suspected
Fang Lu et al.
The Journal of steroid biochemistry and molecular biology, 105(1-5), 150-158 (2007-06-22)
Formation of estrogen metabolites that react with DNA is thought to be a mechanism of cancer initiation by estrogens. The estrogens estrone (E(1)) and estradiol (E(2)) can form catechol estrogen (CE) metabolites, catechol estrogen quinones [E(1)(E(2))-3,4-Q], which react with DNA
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