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R108

Ro 41-0960

solid

别名:

2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone

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关于此项目

经验公式（希尔记法）:
C13H8FNO5
化学文摘社编号:
125628-97-9
分子量:
277.20
NACRES:
NA.77
PubChem Substance ID:
24278193
UNSPSC Code:
12352200
MDL number:
MFCD00078597
Form:
solid
Storage condition:
protect from light
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form

solid

Quality Segment

storage condition

protect from light

color

yellow

solubility

H2O: slightly soluble <0.7 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL, ethanol: soluble

storage temp.

2-8°C

SMILES string

Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F

InChI

1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H

InChI key

RQPAUNZYTYHKHA-UHFFFAOYSA-N

Gene Information

human ... COMT(1312)

Application

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.

Biochem/physiol Actions

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Store tightly sealed at 4 °C, protected from exposure to light.

存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

PPE（个人防护设备）

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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