R108
Ro 41-0960
solid
别名:
2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
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关于此项目
经验公式（希尔记法）:
C13H8FNO5
化学文摘社编号:
分子量:
277.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Storage condition:
protect from light
form
solid
Quality Segment
storage condition
protect from light
color
yellow
solubility
H2O: slightly soluble <0.7 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL, ethanol: soluble
storage temp.
2-8°C
SMILES string
Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
InChI
1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
InChI key
RQPAUNZYTYHKHA-UHFFFAOYSA-N
Gene Information
human ... COMT(1312)
Application
Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.
Biochem/physiol Actions
Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.
Features and Benefits
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Store tightly sealed at 4 °C, protected from exposure to light.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)