R8756
超强辣素
from Euphorbia poisonii, ~95%
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关于此项目
经验公式（希尔记法）:
C37H40O9
CAS Number:
分子量:
628.71
Beilstein:
5371150
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
生物来源
Euphorbia poisonii
质量水平
方案
~95%
储存温度
−20°C
SMILES字符串
[H][C@@]12C=C(C)C(=O)[C@@]1(O)CC(COC(=O)Cc3cc(O)cc(OC)c3)=CC4[C@H]5O[C@]7(Cc6ccccc6)O[C@]5(C[C@@H](C)[C@]24O7)C(C)=C
InChI
1S/C37H40O9/c1-21(2)35-17-23(4)37-29(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)11-22(3)32(34)40)20-43-31(39)15-25-12-27(38)16-28(13-25)42-5/h6-14,16,23,29-30,33,38,41H,1,15,17-20H2,2-5H3/t23-,29?,30-,33-,34-,35-,36-,37-/m1/s1
InChI key
IKYCZSUNGFRBJS-PMIKMUNESA-N
基因信息
rat ... Trpv1(83810)
应用
Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):
- for complex preparation for cryo-electron microscopy structural studies
- to test its effect towards immune responses to P. aeruginosa in sensory neurons associated with the cornea
- to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice
生化/生理作用
Potent VR1 vanilloid receptor agonist that has been used to label the vanilloid receptor in sensory ganglia; activates protein kinase C. Diterpene ester that is related to phorbol, but is not tumorigenic.
Potent VR1 vanilloid receptor agonist.
Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance. It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF).
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Skin Corr. 1A
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
Spontaneous cardiac tamponade in a premature infant.
S Menahem
Journal of paediatrics and child health, 28(6), 467-467 (1992-12-01)
Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons.
J Szolcsanyi et al.
The Journal of pharmacology and experimental therapeutics, 255(2), 923-928 (1990-11-01)
Resiniferatoxin (RTX) has been shown to function as an ultrapotent analog of capsaicin. It is reported here that RTX, like capsaicin, acts selectively on primary sensory neurons in rats to produce ultrastructural alterations and calcitonin gene-related peptide depletion. To evaluate
P K Matsuoka et al.
International urogynecology journal, 23(9), 1147-1153 (2012-05-10)
The objective of the study was to assess the effectiveness of intravesical treatment for painful bladder syndrome (PBS). A systematic review was performed until December 31, 2010. The selection criteria included only randomized controlled trials of PBS patients who received
Tiffany Lin et al.
PLoS pathogens, 17(5), e1009557-e1009557 (2021-05-07)
We report a rapid reduction in blink reflexes during in vivo ocular Pseudomonas aeruginosa infection, which is commonly attributed and indicative of functional neuronal damage. Sensory neurons derived in vitro from trigeminal ganglia (TG) were able to directly respond to
Lejla Zubcevic et al.
eLife, 8 (2019-05-16)
The Transient Receptor Potential Vanilloid 2 (TRPV2) channel is a member of the temperature-sensing thermoTRPV family. Recent advances in cryo-electronmicroscopy (cryo-EM) and X-ray crystallography have provided many important insights into the gating mechanisms of thermoTRPV channels. Interestingly, crystallographic studies of
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