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Merck
CN

R9653

RC-3095

≥95% (HPLC), lyophilized powder

别名:

D-Tpi-Gln-Trp-Ala-Val-Gly-His-Leu-Y(CH2-NH)-Leu-NH2 三氟乙酸盐, （3R）-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羰基-L-谷氨酰胺酰基L-色氨酰-L-丙氨酰-L-valylglycyl-L-组氨- L-亮氨酰-Ψ（CH2-NH）-L-亮氨酰胺三氟乙酸盐，（D-Tpi6,Leu13Ψ（CH2-NH）-Leu14）铃蟾肽（6-14），D-Tpi-Gln- Trp-Ala-Val-Gly-His-Y（CH 2 -NH）-Leu-NH 2 三氟乙酸盐 三氟乙酸盐, （D-Tpi6,Leu13 Ψ（CH2-NH）-Leu14）铃蟾肽（6-14）

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关于此项目

经验公式（希尔记法）:
C56H79N15O9 · xC2HF3O2
化学文摘社编号:
138147-78-1
分子量:
1106.32 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
24899418
UNSPSC Code:
12352200
MDL number:
MFCD07366644

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产品名称

RC-3095, ≥95% (HPLC), lyophilized powder

InChI key

ZHNRKEKBKBWCMF-RWWZSYIDSA-N

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]4Cc5c(CN4)[nH]c6ccccc56)C(C)C

InChI

1S/C56H79N15O9.C2HF3O2/c1-29(2)18-35(25-61-42(50(58)74)19-30(3)4)66-55(79)45(21-34-24-59-28-64-34)68-48(73)27-63-56(80)49(31(5)6)71-51(75)32(7)65-54(78)44(20-33-23-60-39-14-10-8-12-36(33)39)70-52(76)41(16-17-47(57)72)69-53(77)43-22-38-37-13-9-11-15-40(37)67-46(38)26-62-43;3-2(4,5)1(6)7/h8-15,23-24,28-32,35,41-45,49,60-62,67H,16-22,25-27H2,1-7H3,(H2,57,72)(H2,58,74)(H,59,64)(H,63,80)(H,65,78)(H,66,79)(H,68,73)(H,69,77)(H,70,76)(H,71,75);(H,6,7)/t32-,35-,41-,42-,43+,44-,45-,49-;/m0./s1

assay

≥95% (HPLC)

form

lyophilized powder

color

white to off-white

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

RC-3095 是一种有效的 BB2（GRP 偏好）铃蟾肽受体拮抗剂。

Packaging

空气敏感

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000117865
0000045772
0000017801
045M4743V
032M4718V

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Fabricia Petronilho et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(9), 783-789 (2010-04-07)
We report the effects of the gastrin-releasing peptide (GRP) receptor antagonist RC-3095 in an acute inflammation model induced by carrageenan. Male Wistar rats received saline or saline containing 2% lambda-carrageenan into the pleural cavity, with some also receiving RC-3095 3
Gislaine T Rezin et al.
Basic & clinical pharmacology & toxicology, 108(3), 214-219 (2010-12-09)
The pathophysiology of gastritis involves an imbalance between gastric acid attack and mucosal defence. In addition, the gastric mucosal injury results in adenosine triphosphate (ATP) depletion leading to mitochondrial dysfunction. Several studies have shown the association of mitochondrial disorders with
Vanessa A Garcia et al.
Behavioural brain research, 214(2), 456-459 (2010-08-04)
Alterations in attachment behavior might play a role in the dysfunction in social behavior displayed by autistic infants. Here we show that neonatal gastrin-releasing peptide receptor (GRPR) blockade induces a reduction in maternal odor preference, a task involving attachment behavior
Caroline Brunetto de Farias et al.
Protein and peptide letters, 16(6), 650-652 (2009-06-13)
The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10(-3), 10(-6), or 1 microM) decreases nerve growth factor (NGF) secretion measured by enzyme-linked immunosorbent assay (ELISA) in HT-29 human
A M Bajo et al.
British journal of cancer, 90(1), 245-252 (2004-01-08)
The overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and insulin-like growth factors (IGFs) plays a role in the migration and proliferation of endothelial cells in many cancers. Consequently, we investigated the effects
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