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Merck
CN

R9653

Sigma-Aldrich

RC-3095

≥95% (HPLC), lyophilized powder

别名:

D-Tpi-Gln-Trp-Ala-Val-Gly-His-Leu-Y(CH2-NH)-Leu-NH2 三氟乙酸盐, （3R）-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羰基-L-谷氨酰胺酰基L-色氨酰-L-丙氨酰-L-valylglycyl-L-组氨- L-亮氨酰-Ψ（CH2-NH）-L-亮氨酰胺三氟乙酸盐，（D-Tpi6,Leu13Ψ（CH2-NH）-Leu14）铃蟾肽（6-14），D-Tpi-Gln- Trp-Ala-Val-Gly-His-Y（CH 2 -NH）-Leu-NH 2 三氟乙酸盐 三氟乙酸盐, （D-Tpi6,Leu13 Ψ（CH2-NH）-Leu14）铃蟾肽（6-14）

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关于此项目

经验公式（希尔记法）:
C56H79N15O9 · xC2HF3O2
化学文摘社编号:
138147-78-1
分子量:
1106.32 (free base basis)
MDL编号:
MFCD07366644
UNSPSC代码:
12352200
PubChem化学物质编号:
24899418
NACRES:
NA.77

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质量水平

100

方案

≥95% (HPLC)

表单

lyophilized powder

颜色

white to off-white

储存温度

−20°C

SMILES字符串

OC(=O)C(F)(F)F.CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]4Cc5c(CN4)[nH]c6ccccc56)C(C)C

InChI

1S/C56H79N15O9.C2HF3O2/c1-29(2)18-35(25-61-42(50(58)74)19-30(3)4)66-55(79)45(21-34-24-59-28-64-34)68-48(73)27-63-56(80)49(31(5)6)71-51(75)32(7)65-54(78)44(20-33-23-60-39-14-10-8-12-36(33)39)70-52(76)41(16-17-47(57)72)69-53(77)43-22-38-37-13-9-11-15-40(37)67-46(38)26-62-43;3-2(4,5)1(6)7/h8-15,23-24,28-32,35,41-45,49,60-62,67H,16-22,25-27H2,1-7H3,(H2,57,72)(H2,58,74)(H,59,64)(H,63,80)(H,65,78)(H,66,79)(H,68,73)(H,69,77)(H,70,76)(H,71,75);(H,6,7)/t32-,35-,41-,42-,43+,44-,45-,49-;/m0./s1

InChI key

ZHNRKEKBKBWCMF-RWWZSYIDSA-N

Amino Acid Sequence

(D-TPI6, LEU13 y(CH2-NH)-LEU14)BOMBESIN (6-14)

生化/生理作用

RC-3095 是一种有效的 BB2（GRP 偏好）铃蟾肽受体拮抗剂。

包装

空气敏感

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000117865
0000045772
0000017801
045M4743V
032M4718V

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Juliana Presti-Torres et al.
Journal of neural transmission (Vienna, Austria : 1996), 119(3), 319-327 (2011-08-19)
We have previously shown that pharmacological blockade of the gastrin-releasing peptide receptor (GRPR) during the neonatal period in rats produces behavioral features of developmental neuropsychiatric disorders. Here, we show that social interaction deficits in this model are reversed by the
Zul Merali et al.
Behavioural brain research, 216(2), 519-524 (2010-08-31)
Several lines of evidence have implicated bombesin and its mammalian analogue, gastrin-releasing peptide (GRP), in the mediation and/or modulation of the stress response. However, the physiological role of GRP in mediating conditioned fear responses remains to be elucidated. The objective
Caroline Brunetto de Farias et al.
Protein and peptide letters, 16(6), 650-652 (2009-06-13)
The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10(-3), 10(-6), or 1 microM) decreases nerve growth factor (NGF) secretion measured by enzyme-linked immunosorbent assay (ELISA) in HT-29 human
Samira S Valvassori et al.
Journal of neural transmission (Vienna, Austria : 1996), 117(3), 309-316 (2010-02-05)
Previous studies have suggested that bipolar disorder may be associated with oxidative stress. Administration of D: -amphetamine (AMPH) has been put forward as an animal model of mania, and has shown to increase oxidative stress parameters in the rat brain.
Vanessa A Garcia et al.
Behavioural brain research, 214(2), 456-459 (2010-08-04)
Alterations in attachment behavior might play a role in the dysfunction in social behavior displayed by autistic infants. Here we show that neonatal gastrin-releasing peptide receptor (GRPR) blockade induces a reduction in maternal odor preference, a task involving attachment behavior
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