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Merck
CN

R9653

RC-3095

≥95% (HPLC), lyophilized powder

别名:

D-Tpi-Gln-Trp-Ala-Val-Gly-His-Leu-Y(CH2-NH)-Leu-NH2 三氟乙酸盐, （3R）-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羰基-L-谷氨酰胺酰基L-色氨酰-L-丙氨酰-L-valylglycyl-L-组氨- L-亮氨酰-Ψ（CH2-NH）-L-亮氨酰胺三氟乙酸盐，（D-Tpi6,Leu13Ψ（CH2-NH）-Leu14）铃蟾肽（6-14），D-Tpi-Gln- Trp-Ala-Val-Gly-His-Y（CH 2 -NH）-Leu-NH 2 三氟乙酸盐 三氟乙酸盐, （D-Tpi6,Leu13 Ψ（CH2-NH）-Leu14）铃蟾肽（6-14）

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关于此项目

经验公式（希尔记法）:
C56H79N15O9 · xC2HF3O2
化学文摘社编号:
138147-78-1
分子量:
1106.32 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
24899418
UNSPSC Code:
12352200
MDL number:
MFCD07366644

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产品名称

RC-3095, ≥95% (HPLC), lyophilized powder

InChI key

ZHNRKEKBKBWCMF-RWWZSYIDSA-N

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]4Cc5c(CN4)[nH]c6ccccc56)C(C)C

InChI

1S/C56H79N15O9.C2HF3O2/c1-29(2)18-35(25-61-42(50(58)74)19-30(3)4)66-55(79)45(21-34-24-59-28-64-34)68-48(73)27-63-56(80)49(31(5)6)71-51(75)32(7)65-54(78)44(20-33-23-60-39-14-10-8-12-36(33)39)70-52(76)41(16-17-47(57)72)69-53(77)43-22-38-37-13-9-11-15-40(37)67-46(38)26-62-43;3-2(4,5)1(6)7/h8-15,23-24,28-32,35,41-45,49,60-62,67H,16-22,25-27H2,1-7H3,(H2,57,72)(H2,58,74)(H,59,64)(H,63,80)(H,65,78)(H,66,79)(H,68,73)(H,69,77)(H,70,76)(H,71,75);(H,6,7)/t32-,35-,41-,42-,43+,44-,45-,49-;/m0./s1

assay

≥95% (HPLC)

form

lyophilized powder

color

white to off-white

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

RC-3095 是一种有效的 BB2（GRP 偏好）铃蟾肽受体拮抗剂。

Packaging

空气敏感

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000117865
0000045772
0000017801
045M4743V
032M4718V

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访问文档库

Caroline Brunetto de Farias et al.
Protein and peptide letters, 16(6), 650-652 (2009-06-13)
The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10(-3), 10(-6), or 1 microM) decreases nerve growth factor (NGF) secretion measured by enzyme-linked immunosorbent assay (ELISA) in HT-29 human
A M Bajo et al.
British journal of cancer, 90(1), 245-252 (2004-01-08)
The overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and insulin-like growth factors (IGFs) plays a role in the migration and proliferation of endothelial cells in many cancers. Consequently, we investigated the effects
P G Oliveira et al.
Arthritis and rheumatism, 63(10), 2956-2965 (2011-09-29)
To evaluate the antiinflammatory effects of RC-3095 in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA), and to determine the mechanisms of action involved. RC-3095 was administered daily to mice with CIA and mice with AIA
Samira S Valvassori et al.
Journal of neural transmission (Vienna, Austria : 1996), 117(3), 309-316 (2010-02-05)
Previous studies have suggested that bipolar disorder may be associated with oxidative stress. Administration of D: -amphetamine (AMPH) has been put forward as an animal model of mania, and has shown to increase oxidative stress parameters in the rat brain.
Gislaine T Rezin et al.
Basic & clinical pharmacology & toxicology, 108(3), 214-219 (2010-12-09)
The pathophysiology of gastritis involves an imbalance between gastric acid attack and mucosal defence. In addition, the gastric mucosal injury results in adenosine triphosphate (ATP) depletion leading to mitochondrial dysfunction. Several studies have shown the association of mitochondrial disorders with
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