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Merck
CN

RES0114M-A7

MES 钠盐

别名:

2-(N-吗啉基)乙磺酸 钠盐, 4-吗啉乙磺酸 钠盐

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关于此项目

经验公式(希尔记法):
C6H12NNaO4S
化学文摘社编号:
分子量:
217.22
EC Number:
275-203-2
UNSPSC Code:
12161700
NACRES:
NA.21
Beilstein/REAXYS Number:
3765682
MDL number:
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InChI

1S/C6H13NO4S.Na/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);/q;+1/p-1

InChI key

IRHWMYKYLWNHTL-UHFFFAOYSA-M

SMILES string

[Na+].[O-]S(=O)(=O)CCN1CCOCC1

biological source

synthetic

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin and microbial, tested

useful pH range

5.5-6.7

pKa 

6.1

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

Quality Level

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Packaging

该产品有以下包装尺寸:
RES0114M-A701X: 100g容器
RES0114M-A702X:1kg包装
RES0114M-A704X: 10kg容器
RES0114M-A705X: 25kg容器

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

HEPES是一种生物缓冲液,通常被称为Good′s缓冲液。MES的pKa为5.96,这使MES成为细胞培养基和基于蛋白质的缓冲液配方的理想候选者,以维持溶液中的稳定环境。MES钠盐被认为是对培养细胞系无毒的一种物质高度可溶于水并可为溶液提供高澄清度。

MES那样用于细胞培养基、生物制药缓冲制剂上游和下游以及诊断试剂。基于MES的缓冲液可用于抗体、肽、蛋白质和血液成分的纯化生物过程。

General description

我们用于生物制药加工的SAFC®系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity 计划规定的要求

M-Clarity 计划

缓冲液质量是生物制药工艺成功的关键,因为缓冲液几乎在每一个生产步骤中都是必不可少的。

我们广泛的缓冲材料产品线经过妥善管控,可根据您的需求量身定制。从低风险应用的非 GMP 等级,到高风险应用的 IPEC-PQG GMP标准,我们的产品可满足您的所有制造需求。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Padmavati Venkataraman et al.
The Journal of biological chemistry, 280(22), 21463-21472 (2005-03-24)
The influenza virus M2 proton-selective ion channel activity facilitates virus uncoating, a process that occurs in the acidic environment of the endosome. The M2 channel causes acidification of the interior of the virus particle, which results in viral protein-protein dissociation.
Taras P Pasternak et al.
Plant physiology, 129(4), 1807-1819 (2002-08-15)
Culturing leaf protoplast-derived cells of the embryogenic alfalfa (Medicago sativa subsp. varia A2) genotype in the presence of low (1 microM) or high (10 microM) 2, 4-dichlorophenoxyacetic acid (2,4-D) concentrations results in different cell types. Cells exposed to high 2,4-D
Cecilia Gelfi et al.
Electrophoresis, 23(10), 1517-1523 (2002-07-13)
A large number of point mutations in the p53 gene have been detected by capillary zone electrophoresis via single-strand conformation polymorphism (SSCP) analysis. A much improved detection sensitivity was obtained via the following modifications in running conditions: use of low-viscosity
Elisabet Fuguet et al.
Electrophoresis, 29(13), 2841-2851 (2008-06-12)
The performance of the most common and also some other less common CE buffers has been tested for the pKa determination of several types of compounds (pyridine, amines, and phenols). The selected buffers cover a pH ranging from 3.7 to
Ekta G Ahuja et al.
Acta crystallographica. Section D, Biological crystallography, 60(Pt 6), 1129-1131 (2004-05-26)
Phenazines are broad-spectrum antibiotic metabolites produced by organisms such as Pseudomonas and Streptomyces. Phenazines have been shown to enhance microbial competitiveness and the pathogenic potential of the organisms that synthesize them. PhzA (163 residues, approximate molecular weight 18.7 kDa) is

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