方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: ~18 mg/mL
H2O: <2 mg/mL
储存温度
2-8°C
SMILES字符串
NC(=O)c1ccc2[nH]ccc2c1
生化/生理作用
SD-169 is a p38α-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor.
SD-169 is an orally active, ATP-competitve, p38α-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50 = 3.2 nM) than p38β MAP kinase (IC50 = 122 nM).
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Robert R Myers et al.
Experimental neurology, 184(2), 606-614 (2004-02-11)
Tumor necrosis factor alpha (TNF)-induced cellular signaling through the p38 mitogen-activated protein kinase (p38 MAPK) pathway plays a critical role in Wallerian degeneration and subsequent regeneration, processes that depend on Schwann cell (SC) activity. TNF dose-dependently induces Schwann cell and
Satyanarayana Medicherla et al.
The Journal of pharmacology and experimental therapeutics, 318(1), 99-107 (2006-04-11)
Mitogen-activated protein kinases (MAPKs) and heat shock proteins (HSPs) are ubiquitous proteins that function within T cells in both normal and stress-related pathophysiological states, including type 1 diabetes. The nonobese diabetic (NOD) mouse spontaneously develops T cell-mediated autoimmune pancreatic beta
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