S0826
S-PMH
≥98% (HPLC)
别名:
(Z)-5-(4-(ethylthio)benzylidene)-hydantoin, (Z)-5-[4-(Ethylthio)benzylidene]imidazolidine-2,4-dione, 5-(4-Ethylsulfanylbenzylidene)imidazolidine-2,4-dione
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H12N2O2S
化学文摘社编号:
分子量:
248.30
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C12H12N2O2S/c1-2-17-9-5-3-8(4-6-9)7-10-11(15)14-12(16)13-10/h3-7H,2H2,1H3,(H2,13,14,15,16)/b10-7-
SMILES string
CCSc1ccc(cc1)\C=C2/NC(=O)NC2=O
InChI key
UWMDBDYLNJITCD-YFHOEESVSA-N
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes.
S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.
Features and Benefits
This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
商品
Sigma-Aldrich offers many products related to calcitonin gene-related peptides for your research needs.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持