S116
(±)-止呕灵
别名:
(±)-5-氨基磺酰基-N-[(1-乙基-2-吡咯烷基)甲基]-2-甲氧基苯甲酰胺, (±)-N-1-(乙基-2-吡咯基甲基)-2-甲氧基-5-氨磺酰苯甲酰胺
SMILES字符串
CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
InChI
1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
InChI key
BGRJTUBHPOOWDU-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
法规信息
新产品
此项目有
Giuseppina De Simone et al.
Journal of medicinal chemistry, 49(18), 5544-5551 (2006-09-01)
An approach for designing bioreductive, hypoxia-activatable carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the tumor-associated isoforms is reported. Sulfonamides incorporating 3,3'-dithiodipropionamide/2,2'-dithiodibenzamido moieties were prepared and reduced enzymatically/chemically in conditions present in hypoxic tumors, leading to thiols. The X-ray crystal structure
Isao Nishimori et al.
Journal of medicinal chemistry, 49(6), 2117-2126 (2006-03-17)
We have cloned and sequenced Helicobacter pylori alpha-class carbonic anhydrase (hpCA) from patients with different gastric mucosal lesions, including gastritis (n=15), ulcer (n=6), and cancer (n=16). Although several polymorphisms were newly identified such as 12Ala, 13Thr, 16Ile, and 168Phe, there
Davide Dulcis et al.
Neuron, 95(6), 1319-1333 (2017-09-05)
Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 17(13), 4503-4509 (2009-05-20)
The beta-carbonic anhydrase (CA, EC 4.2.1.1) from the fungal pathogen Candida albicans (Nce103) is involved in a CO(2) sensing pathway critical for the pathogen life cycle and amenable to drug design studies. Herein we report an inhibition study of Nce103
Isao Nishimori et al.
Journal of medicinal chemistry, 48(24), 7860-7866 (2005-11-24)
A lately discovered carbonic anhydrase (hCA, EC 4.2.1.1), the mitochondrial hCA VB, was cloned, expressed, and purified. Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat =
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持