S128
N-Methylspiperone hydrochloride
solid
别名:
N-Methyl-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro-[4.5]decan-4-one hydrochloride
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关于此项目
经验公式（希尔记法）:
C24H28FN3O2 · HCl
化学文摘社编号:
分子量:
445.96
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C24H28FN3O2.ClH/c1-26-18-28(21-6-3-2-4-7-21)24(23(26)30)13-16-27(17-14-24)15-5-8-22(29)19-9-11-20(25)12-10-19;/h2-4,6-7,9-12H,5,8,13-18H2,1H3;1H
SMILES string
Cl.CN1CN(c2ccccc2)C3(CCN(CCCC(=O)c4ccc(F)cc4)CC3)C1=O
InChI key
OGOQOKYYPNFSOL-UHFFFAOYSA-N
form
solid
color
light yellow
solubility
0.1 M HCl: soluble, ethanol: soluble
Quality Level
General description
N-Methylspiperone acts as a D2 dopamine receptor antagonist. It is an analog of spiperone. The isotope 3-N-[11C]methylspiperone ([11C]NMSP) is widely used in dopamine receptor imaging in positron emission tomography (PET).
Application
Reference standard.
Biochem/physiol Actions
D2 dopamine receptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Scarselli et al.
European journal of pharmacology, 397(2-3), 291-296 (2000-06-14)
An N-terminal dopamine D(2s) receptor clone was constructed and coexpressed in COS-7 cells together with a separate gene fragment coding for the C-terminal sequence of the dopamine D(2s) receptor. The truncated receptor (referred to as D(2trunc)) contained transmembrane domains I-V
M Yoshimura et al.
Journal of the neurological sciences, 197(1-2), 89-92 (2002-05-09)
A 66-year-old woman presented with a 3-year history of progressive right-sided hemiparkinsonism manifested by a right-hand resting tremor and right-sided bradykinesia. Magnetic resonance imaging (MRI) of the brain revealed a non-enhanced polycystic mass in the left midbrain. (11)C-methylspiperone ((11)C-NMSP) and
O Inoue et al.
Journal of neural transmission (Vienna, Austria : 1996), 106(11-12), 1099-1104 (2000-01-29)
Competitive inhibition of 3H-raclopride (RAC) and 3H-N-methylspiperone (NMSP) binding against haloperidol, raclopride and NMSP was measured in the mouse striatum. 3H-RAC binding was more sensitive to competitive inhibition by all three compounds compared with 3H-NMSP. For example, 0.3 mg/kg of
R Hosoi et al.
Journal of neural transmission (Vienna, Austria : 1996), 109(9), 1139-1149 (2002-08-31)
In order to clarify whether changes in brain concentrations of the second messenger cyclic AMP (cAMP) affect in vivo receptor binding in the brain, the effects of rolipram, a selective inhibitor of phosphodiesterase type 4 (PDE(4)), on dopamine receptor binding
Takuto Hideyama et al.
Archives of neurology, 63(12), 1719-1722 (2006-12-19)
Patients with amyotrophic lateral sclerosis (ALS) sometimes exhibit parkinsonism, but the lesion responsible for parkinsonism has not been extensively studied. To test whether nigrostriatal system dysfunction is responsible for parkinsonism in ALS. From the 182 ALS patients who were admitted
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