Name: STX64
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₄H₁₅NO₅S

CAS Number:

288628-05-7

分子量:

309.34

MDL编号:

MFCD12912443

UNSPSC代码:

51111800

PubChem化学物质编号:

329824496

NACRES:

NA.77

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方案

≥98% (HPLC)

表单

powder

颜色

white

溶解性

DMSO: >20 mg/mL

储存温度

2-8°C

SMILES字符串

NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1

InChI

1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)

InChI key

DSLPMJSGSBLWRE-UHFFFAOYSA-N

基因信息

human ... STS(412)

生化/生理作用

STX64 is a potent, irreversible inhibitor of steroid sulfatase.

STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC₅₀ = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.