S198
N6-p-Sulfophenyladenosine sodium salt
solid
别名:
4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt, SPA
表单
solid
颜色
off-white
溶解性
DMSO: soluble
H2O: soluble
储存温度
−20°C
生化/生理作用
A1 adenosine receptor agonist.
法律信息
Sold under license from the National Institutes of Health.
免责声明
Hygroscopic. Photosensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
E A van Schaick et al.
The Journal of pharmacology and experimental therapeutics, 287(1), 21-30 (1998-10-09)
Studies were designed to investigate differences in pharmacokinetics and pharmacodynamics of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine (SPA) between lean and obese Zucker rats. In conscious rats, time courses of the effect on heart rate and parameters of lipid metabolism
K A Jacobson et al.
Journal of medicinal chemistry, 35(22), 4143-4149 (1992-10-30)
A series of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine was synthesized, revealing that N6-(p-sulfophenyl)adenosine (10b) is a moderately potent (Ki vs [3H]PIA in rat cortical membranes was 74nM) and A1-selective (120-fold) adenosine agonist, of exceptional aqueous solubility of > 1.5
Haley S Province et al.
PloS one, 15(12), e0243986-e0243986 (2020-12-17)
Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A1 receptors (A1AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injection of the selective A1AR agonist (Cl-ENBA, 5'-chloro-5'-deoxy-N6-endo-norbornyladenosine)
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