S2947
Anti-Synapsin II (C-terminal) 兔抗
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-SYN2, Anti-SYNAPSIN 2, Anti-SYNII, Anti-SYNIIa, Anti-SYNIIb
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~74 kDa (synapsin IIa)
species reactivity
human, mouse, rat
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 0.25-0/5 μg/mL using extracts of HEK-293T cells expressing human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SYN2(6854)
mouse ... Syn2(20965)
rat ... Syn2(29179)
General description
Synapsins are a family of neuron-specific phosphoproteins that are localized on the cytoplasmic surface of small synaptic vesicles. Synapsins are ubiquitously expressed in neurons. The synapsin 2 (Syn2) gene is located on human chromosome 3p25. It belongs to the neuronal phosphoprotein family.
Immunogen
synthetic peptide corresponding to amino acids 569-586 of rat synapsin IIa isoform, conjugated to KLH. This sequence is identical in rat synapsin IIa, human synapsin IIa, and mouse synapsin II, and is not found in rat and human synapsin IIb.
Application
Anti-Synapsin II (C-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Anti-Synapsin II(C-terminal) specifically recognizes human, rat and mousesynapsin II.
Synapsins regulate synaptic vesicle clustering and the formation of synaptic terminals. Synapsin II (Syn2) is involved in the formation of synaptic terminals during neuronal development. It can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. It is proposed as a candidate associated with increased vulnerability to schizophrenia. It plays an important role in synaptogenesis and neurotransmitter release. Syn2 also helps to locate nitric oxide synthase to the vicinity of its targets.
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slightturbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Distinct roles of synapsin I and synapsin II during neuronal development
Ferreira A, et al.
Molecular Medicine, 4(1), 22-28 (1998)
Association of synapsin 2 with schizophrenia in families of Northern European ancestry
Saviouk V, et al.
Schizophrenia Research, 96(1-3), 100-111 (2007)
Role of presynaptic phosphoprotein synapsin II in schizophrenia
Molinaro L, et al.
World Psychiatry, 5(3), 260-260 (2015)
Essential functions of synapsins I and II in synaptic vesicle regulation
Rosahl TW, et al.
Nature, 375(6531), 488-493 (1995)
Diane T Stephenson et al.
Molecular autism, 2(1), 7-7 (2011-05-18)
The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus callosum. The goal of this study was to
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持