Biochem/physiol Actions
Staphostatins are a novel group of inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases. Staphostatin A and staphostatin B from S. aureus have been characterized in details. Staphostatins interact specifically with this target proteinases forming tight 1:1 and stable non-covalent complex, staphostain A with staphopain A and staphostain B with staphopain B with no cross interaction observed and with very narrow specificity limited to staphopains
The loss of staphostatin B (SspC) expression in S. aureus and the subsequent increase in secreted protease staphopain B (SspB) activity resulted in numerous defects including reduced growth, decreased autolytic activity, resistance to lysis by S. aureus phages, and the inability to secrete proteins into the extracellular matrix.
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11 - Combustible Solids
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WGK 3
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flash_point_c
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Lindsey N Shaw et al.
Journal of bacteriology, 187(5), 1751-1762 (2005-02-18)
The cytoplasmic protein SspC of Staphylococcus aureus, referred to as staphostatin B, is a very specific, tightly binding inhibitor of the secreted protease staphopain B (SspB). SspC is hypothesized to protect intracellular proteins against proteolytic damage by prematurely folded and
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