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S3944

SEW2871

Name: SEW2871
Brand: SIGMA

≥98% (HPLC), solid

别名:

5- [4-苯基-5-(三氟甲基)-2-噻吩基]-3- [3-(三氟甲基)苯基]-1,2,4-恶二唑

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₀F₆N₂OS

化学文摘社编号:

256414-75-2

分子量:

440.36

NACRES:

NA.77

PubChem Substance ID:

24724607

UNSPSC Code:

12352211

MDL number:

MFCD00096600

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

mp

94.5-95.3 °C

solubility

DMSO: ≥10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F

InChI

1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H

InChI key

OYMNPJXKQVTQTR-UHFFFAOYSA-N

Gene Information

human ... S1PR1(1901), S1PR2(9294), S1PR3(1903), S1PR4(8698), S1PR5(53637)

Application

SEW2871已被用作鞘氨醇-1磷酸酯（S1P）受体激动剂，用于测定重构血浆载脂蛋白（ApoM) /S1P对小鼠血管通透性的作用。

SEW2871可用于模拟HUVEC中的1-磷酸鞘氨醇的作用，以研究长穿透素3所产生的先天免疫力。

Biochem/physiol Actions

SEW2871是1-磷酸鞘氨醇受体的选择性激动剂。其会通过显著延长室性心动过速和室颤的持续时间，加剧再灌注性心律失常。 SEW2871可通过影响淋巴细胞归巢和细胞迁移来调节炎症反应。通过抑制促炎分子，SEW2871可减少因缺血引起的急性肾衰竭。

新型选择性人鞘氨醇-1-磷酸亚型1（S1P1）受体激动剂。

Features and Benefits

该化合物在受体分类和信号转导手册中溶血磷脂受体页面中进行了详细介绍。想要浏览手册的其他页面，请单击此处。

Packaging

光敏。

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure.

Yang-Hee Kim et al.

Journal of biomedical materials research. Part A, 104(4), 942-956 (2015-12-26)

In this study, the wound closure of mouse skin defects was examined in terms of recruitment of mesenchymal stem cells (MSC) and macrophages. For the cells recruitment, stromal derived factor-1 (SDF-1) of a MSC recruitment agent and sphingosine-1 phosphate agonist

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.

Jasmin Fettel et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(2), 1711-1726 (2018-09-07)

Sphingosine-1-phosphate (S1P) is involved in the regulation of important cellular processes, including immune-cell trafficking and proliferation. Altered S1P signaling is strongly associated with inflammation, cancer progression, and atherosclerosis; however, the mechanisms underlying its pathophysiologic effects are only partially understood. This

S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias.

Yayoi T Tsukada et al.

Journal of cardiovascular pharmacology, 50(6), 660-669 (2007-12-20)

Sphingosine-1-phosphate (S1P) has been considered to play an important role in ischemia/reperfusion (I/R) injury. We used SEW2871 (SEW), a novel receptor-selective agonist for S1P1, to elucidate the role of S1P1 in myocardial I/R. Isolated perfused rat hearts exposed to S1P

Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease.

Frdoos Al Fadel et al.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(6), 1637-1645 (2016-12-23)

Ectopic lipid accumulation in hepatocytes has been identified as a risk factor for the progression of liver fibrosis and is strongly associated with obesity. In particular, the saturated fatty acid palmitate is involved in initiation of liver fibrosis via formation

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.

Timothy M Doyle et al.

Pain, 161(9), 2107-2118 (2020-04-18)

Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. These adverse effects hamper opioid

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全球贸易项目编号

货号	GTIN
S3944-1MG	04061826676905
S3944-5MG	04061833265086

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