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文件

S4568

SCH 58261

Name: SCH 58261
Brand: SIGMA

≥98% (HPLC), solid

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别名:

7-(2-苯乙基)-5-氨基-2-(2-呋喃基)-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]嘧啶

经验公式（希尔记法）:

C₁₈H₁₅N₇O

CAS号:

160098-96-4

分子量:

345.36

MDL编号:

MFCD00933778

PubChem化学物质编号:

329824547

NACRES:

NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

颜色

off-white

溶解性

DMSO: soluble >10 mg/mL
H₂O: insoluble

SMILES string

Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5

InChI

1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

InChI key

UTLPKQYUXOEJIL-UHFFFAOYSA-N

应用

SCH 58261被用于阻断A2α腺苷酸受体，以研究神经元中前列腺酸性磷酸酶的信号传导。⁴

生化/生理作用

SCH 58261能够降低TNF-α、Fas-L、Bax表达以及JNK-MAPK通路的活化水平。它具有神经保护作用，因为它可以减少神经元的脱髓鞘。 SCH 58261能够提高多巴胺的分泌浓度并引发运动致敏，这是一个有吸引力的潜在帕金森氏病治疗方法。

A_2A 腺苷受体拮抗剂。

特点和优势

《受体分类和信号转导》手册的腺苷受体页有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Selective A

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