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S4568

SCH 58261

Name: SCH 58261
Brand: SIGMA

≥98% (HPLC), adenosine receptor antagonist, solid

别名:

7-(2-苯乙基)-5-氨基-2-(2-呋喃基)-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]嘧啶

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₅N₇O

化学文摘社编号:

160098-96-4

分子量:

345.36

UNSPSC Code:

12352200

PubChem Substance ID:

329824547

NACRES:

NA.77

MDL number:

MFCD00933778

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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产品名称

SCH 58261, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble >10 mg/mL, H₂O: insoluble

SMILES string

Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5

InChI

1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

InChI key

UTLPKQYUXOEJIL-UHFFFAOYSA-N

Application

SCH 58261被用于阻断A2α腺苷酸受体，以研究神经元中前列腺酸性磷酸酶的信号传导。⁴

Biochem/physiol Actions

A_2A 腺苷受体拮抗剂。

SCH 58261能够降低TNF-α、Fas-L、Bax表达以及JNK-MAPK通路的活化水平。它具有神经保护作用，因为它可以减少神经元的脱髓鞘。 SCH 58261能够提高多巴胺的分泌浓度并引发运动致敏，这是一个有吸引力的潜在帕金森氏病治疗方法。

Features and Benefits

《受体分类和信号转导》手册的腺苷受体页有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Selective A

Cristiani F Bortolatto et al.

Metabolic brain disease, 32(6), 1919-1927 (2017-08-11)

The aim of the present study was to investigate the effects of SCH58261, a selective adenosine A

Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T

Mushtaq A Ansari et al.

Molecular and cellular neurosciences, 82, 76-87 (2017-05-04)

Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by stereotypical repetitive behavior, impaired social interaction, and deficits in communication. The BTBR T

Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4

Sheikh F Ahmad et al.

Journal of neuroimmunology, 311, 59-67 (2017-08-16)

Autism is a complex heterogeneous neurodevelopmental disorder; previous studies have identified altered immune responses among individuals diagnosed with autism. An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in neurodevelopmental behavioral and autism

Neuronal adenosine A2A receptors signal ergogenic effects of caffeine.

Aderbal S Aguiar et al.

Scientific reports, 10(1), 13414-13414 (2020-08-10)

Caffeine is one of the most used ergogenic aid for physical exercise and sports. However, its mechanism of action is still controversial. The adenosinergic hypothesis is promising due to the pharmacology of caffeine, a nonselective antagonist of adenosine A1 and

Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells.

Sven Berberich et al.

Scientific reports, 7(1), 17040-17040 (2017-12-08)

Mechanisms underlying information storage have been depicted for global cell-wide and pathway-specific synaptic plasticity. Yet, little is known how these forms of plasticity interact to enhance synaptic competition and network stability. We examined synaptic interactions between apical and basal dendrites

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全球贸易项目编号

货号	GTIN
S4568-25MG	04061832093512
S4568-5MG	04061836927660

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