S6389
1-硬脂酰-2-花生酰-sn-甘油
~98%, suitable for stimulation of protein kinase C derived from liver cells, liquid
别名:
1-十八酰基-2-([顺,顺,顺,顺]-5,8,11,14-二十碳四烯酰)-sn-甘油, 2-花生四烯酰-1-硬脂酰-sn-甘油
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关于此项目
经验公式（希尔记法）:
C41H72O5
化学文摘社编号:
分子量:
645.01
PubChem Substance ID:
UNSPSC Code:
41106305
Beilstein/REAXYS Number:
2198923
MDL number:
Assay:
~98%
Form:
liquid
assay
~98%
form
liquid
impurities
1,3-isomer, trace
solubility
chloroform: 20 mg/ml
suitability
suitable for stimulation of protein kinase C derived from liver cells
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
InChI
1S/C41H72O5/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(44)46-39(37-42)38-45-40(43)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,39,42H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3/b13-11-,19-17-,24-22-,30-28-
InChI key
NSXLMTYRMFVYNT-LGHBDAFPSA-N
Application
1-Stearoyl-2-arachidonoyl-sn-glycerol was used to study Ca+2 signaling.5,6
Biochem/physiol Actions
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacyl glycerol (DAG) that allosterically activates PKC and other proteins that affect cell growth, development, survival, apoptosis, carcinogenesis and metastasis.3 It activates transient receptor potential channels 3 and 6 that regulates the intracellular free calcium levels.4
Packaging
密封安瓿瓶
Disclaimer
本品在储存中可能发生异构化。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
J O Hindenes et al.
The Journal of biological chemistry, 275(10), 6857-6867 (2000-03-04)
sn-1,2-diacylglycerol (DAG), a key intermediate in lipid metabolism, activates protein kinase C and is a fusogen. Phosphoinositides, the main sources of DAG in cell signaling, contain mostly stearoyl and arachidonoyl in the sn-1 and -2 positions, respectively. The polymorphic behavior
J Florin-Christensen et al.
The Journal of biological chemistry, 267(21), 14783-14789 (1992-07-25)
We have examined the metabolism of three radiolabeled 1,2-diacylglycerols (DGs) in NIH 3T3 fibroblasts. Since the lipids used are not appreciably taken up by the cells, we used a phosphatidylserine (PS)-based liposome fusion system to rapidly associate the lipid species
Elizabeth M Deacon et al.
Journal of cell science, 115(Pt 5), 983-989 (2002-03-01)
Protein kinase C (PKC) is a family of 11 isoenzymes that are differentially involved in the regulation of cell proliferation. PKC-betaII, a mitotic lamin kinase, has been shown previously to translocate to the nucleus at G(2)/M and this was coupled