S6510
N-琥珀酰-Leu-Leu-Val-Tyr-7-氨基-4-甲基香豆素
≥90% (HPLC), Chymotrypsin substrate, powder
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关于此项目
经验公式（希尔记法）:
C40H53N5O10
化学文摘社编号:
分子量:
763.88
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
N-琥珀酰-Leu-Leu-Val-Tyr-7-氨基-4-甲基香豆素, ≥90% (HPLC)
SMILES string
CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)
InChI key
UVFAEQZFLBGVRM-UHFFFAOYSA-N
assay
≥90% (HPLC)
form
powder
solubility
0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Application
用N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素测定水稻Jurkat细胞裂解液6和粗细胞裂解液中蛋白酶体类糜蛋白酶活性。7
Biochem/physiol Actions
在存在胰凝乳蛋白酶样酶活性的情况下，荧光团，7-氨基-4-甲基香豆素是从N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素中释放的。所获得的荧光可作为酶活性的量度。6
General description
用作胰凝乳蛋白酶样酶的荧光底物，例如组织蛋白酶B和钙蛋白酶，其与程序性细胞死亡有关。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
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The Biochemical journal, 335 ( Pt 3), 637-642 (1998-10-31)
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O Ullrich et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(8), 1460-1462 (2001-06-02)
M Kroll et al.
Chemistry & biology, 6(10), 689-698 (1999-10-06)
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R Guerra-Sá et al.
Experimental parasitology, 109(4), 228-236 (2005-03-10)
Proteasomes are multi-subunit proteases involved in several mechanisms and thought to contribute to the regulation of cellular homeostasis. Here, we report for the first time biochemical evidence for the existence of a ubiquitin-proteasome proteolytic pathway in this parasite. Proteasomes from
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