主要文件

查看所有文档

S8307

SB 203580

Name: SB 203580
Brand: SIGMA

≥98% (HPLC), solid, p38 MAPK inhibitor

别名:

4-（4-氟苯基）-2-（4-甲基亚磺酰苯基）-5-（4-吡啶基）-1H-咪唑

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₁H₁₆FN₃OS

化学文摘社编号:

152121-47-6

分子量:

377.43

UNSPSC Code:

12352200

PubChem Substance ID:

24899788

NACRES:

NA.77

MDL number:

MFCD00922198

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

SB 203580, solid, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

−20°C

SMILES string

CS(=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChI key

CDMGBJANTYXAIV-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544), CYP2C19(1557), CYP2C9(1559), CYP2D6(1565), CYP3A4(1576), IL1B(3553), MAPK14(1432), MAPK8IP2(23542), RAF1(5894), TNF(7124)

正在寻找类似产品? 访问产品对比指南

Application

使用SB 203580处理MDCK细胞以研究MAPK信号转导在诱导细胞膜的高渗性和钾耗竭中的作用。¹⁶ 它被用于抑制小鼠皮层神经元¹⁷和人肝细胞癌细胞系中的MAPK信号转导。¹⁸

Biochem/physiol Actions

SB 203580是一种吡啶基咪唑，可抑制MAPKAP激酶-2的活化，以及在体内抑制热休克蛋白（HSP）27对IL-1、细胞应激和细菌内毒素的反应磷酸化。它不可抑制JNK或p42 MAP激酶，因此可用于研究p38 MAPK和MAPKAP激酶-2的生理作用和靶点。已有研究显示它可诱导丝氨酸/苏氨酸激酶Raf-1的活化，并且据报道其可抑制细胞因子的产生。

Features and Benefits

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面，请点击此处。

该化合物是激酶磷酸酶生物学研究的推荐产品。点击此处，了解更多精选激酶磷酸酶生物学产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica.

Harini Lakshminarasimhan et al.

Scientific reports, 7(1), 4533-4533 (2017-07-05)

Doxorubicin (DOX), a common chemotherapeutic agent, impairs synaptic plasticity. DOX also causes a persistent increase in basal neuronal excitability, which occludes serotonin-induced enhanced excitability. Therefore, we sought to characterize and reverse DOX-induced physiological changes and modulation of molecules implicated in

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure.

Ying Yang et al.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(5), 2130-2143 (2017-08-16)

C1q and tumour necrosis factor-related protein 1 (CTRP1) possesses anti-atherogenic and anti-inflammatory effects. This study investigated whether the CTRP1 levels in the plasma and epicardial adipose tissue (EAT) were associated with congestive heart failure (CHF) and to disclose possible molecular

Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha.

S Hashimoto et al.

Biochemical and biophysical research communications, 258(2), 443-447 (1999-05-18)

We examined the regulatory role of a reduction/oxidation (redox) control protein, thioredoxin (TRX), in tumor necrosis factor-alpha (TNF-alpha)-induced p38 MAP kinase activation and p38 MAP kinase-mediated cytokine expression utilizing TRX-transfected murine L929 cells (TRX14). The results showed that TNF-alpha-induced p38

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis.

Jianxin Huo et al.

Cells, 9(3) (2020-03-04)

: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various environmental stress. However, whether ASK1 plays

Epigenetic programming of the rRNA promoter by MBD3.

Shelley E Brown et al.

Molecular and cellular biology, 27(13), 4938-4952 (2007-04-25)

Within the human genome there are hundreds of copies of the rRNA gene, but only a fraction of these genes are active. Silencing through epigenetics has been extensively studied; however, it is essential to understand how active rRNA genes are

查看所有相关文献

商品

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

全球贸易项目编号

货号	GTIN
S8307-1MG	04061836960735

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持