S9066
SKF-89976A
>98% (HPLC), solid
别名:
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
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关于此项目
经验公式（希尔记法）:
C22H25NO2 · HCl
化学文摘社编号:
分子量:
371.90
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
>98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble 20 mg/mL
H2O: insoluble
创始人
GlaxoSmithKline
储存温度
2-8°C
SMILES字符串
Cl[H].OC(=O)C1CCCN(CC\C=C(/c2ccccc2)c3ccccc3)C1
InChI
1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H
InChI key
SNGGBKYQZVAQKA-UHFFFAOYSA-N
基因信息
human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Slc6a1(79212), Slc6a12(50676)
应用
SKF-89976A was used to study the role of adenosine receptors in uptake of GABA transport.4,5
生化/生理作用
GABA transporter type 1 (GAT-1) inhibitor that crosses the blood brain barrier.
SKF-89976A contains a cyclic amino acid with lipophilic moiety that enables the compound to cross the blood-brain barrier.1,2 It decreases the excitotoxic swelling of chick retina cells by blocking the glutamate-induced GABA release.3
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Maria Kukley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(24), 8320-8331 (2010-06-18)
NG2-expressing oligodendrocyte precursor cells (OPCs) are ubiquitous and generate oligodendrocytes throughout the young and adult brain. Previous work has shown that virtually every NG2 cell receives synaptic input from many axons, but the meaning of this signaling is not understood.
Christopher B Ransom et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(22), 7672-7684 (2010-06-04)
Ambient GABA in the brain activates GABA(A) receptors to produce tonic inhibition. Membrane potential influences both GABA transport and GABA(A) receptors and could thereby regulate tonic inhibition. We investigated the voltage dependence of tonic currents in cultured rat hippocampal neurons
David J Rossi et al.
The Journal of physiology, 548(Pt 1), 97-110 (2003-02-18)
Cerebellar granule cells are inhibited phasically by GABA released synaptically from Golgi cells, but are inhibited more powerfully by tonic activity of high affinity alpha 6 subunit-containing GABAA receptors. During development the tonic activity is generated by the accumulation of
Adriana Galvan et al.
Journal of neurophysiology, 94(2), 990-1000 (2005-04-15)
Neurons in the external and internal segment of the globus pallidus (GPe and GPi, respectively) receive substantial GABAergic inputs from the striatum and through axon collaterals of neighboring pallidal neurons. The effects of GABA on pallidal activity depend on the
G D Zeevalk et al.
Molecular and chemical neuropathology, 29(1), 27-36 (1996-09-01)
Acute excitotoxicity in the chick retina is characterized by cellular swelling and the subsequent selective release of GABA. In order to understand the source of GABA release, embryonic day 15 retina were incubated with 1 mM glutamate for 30 min
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