S9192
Ser-Leu-Ile-Gly-Lys-Val-amide
≥95% (HPLC), Proteinase-activated receptor-2 (PAR2) activator, solid
别名:
PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2
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关于此项目
经验公式（希尔记法）:
C28H54N8O7
CAS Number:
分子量:
614.78
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
Product Name
Ser-Leu-Ile-Gly-Lys-Val-amide, ≥95% (HPLC), solid
质量水平
方案
≥95% (HPLC)
表单
solid
UniProt登记号
储存温度
−20°C
SMILES字符串
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O
InChI
1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1
InChI key
HOWDUIVVWDUEED-WAUHAFJUSA-N
基因信息
mouse ... Insrr(23920)
相关类别
Amino Acid Sequence
Ser-Leu-Ile-Gly-Lys-Val-NH2
生化/生理作用
Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.
Proteinase-activated receptor-2 (PAR2)-activating peptide.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
其他说明
Lyophilized from 0.1% TFA in H2O
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles.
Kaushik Das et al.
Scientific reports, 8(1), 7357-7357 (2018-05-11)
Metastasis, the hallmark of cancer propagation is attributed by the modification of phenotypic/functional behavior of cells to break attachment and migrate to distant body parts. Cancer cell-secreted microvesicles (MVs) contribute immensely in disease propagation. These nano-vesicles, generated from plasma membrane
Hendrik Ungefroren et al.
Molecular pharmacology, 92(5), 519-532 (2017-08-27)
Transforming growth factor-
D Quanjun et al.
European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)
Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)
Abhishek Roy et al.
The Journal of biological chemistry, 292(33), 13688-13701 (2017-05-20)
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either
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