S9192
Ser-Leu-Ile-Gly-Lys-Val-amide
≥95% (HPLC), Proteinase-activated receptor-2 (PAR2) activator, solid
别名:
PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C28H54N8O7
化学文摘社编号:
分子量:
614.78
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
Ser-Leu-Ile-Gly-Lys-Val-amide, ≥95% (HPLC), solid
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O
InChI key
HOWDUIVVWDUEED-WAUHAFJUSA-N
InChI
1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1
assay
≥95% (HPLC)
form
solid
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Insrr(23920)
Biochem/physiol Actions
Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.
Proteinase-activated receptor-2 (PAR2)-activating peptide.
Other Notes
Lyophilized from 0.1% TFA in H2O
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
Bono F, et al.
Biochemical and Biophysical Research Communications, 241(3), 762-764 (1997)
Hendrik Ungefroren et al.
Molecular pharmacology, 92(5), 519-532 (2017-08-27)
Transforming growth factor-
D Quanjun et al.
European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)
Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)
The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles.
Kaushik Das et al.
Scientific reports, 8(1), 7357-7357 (2018-05-11)
Metastasis, the hallmark of cancer propagation is attributed by the modification of phenotypic/functional behavior of cells to break attachment and migrate to distant body parts. Cancer cell-secreted microvesicles (MVs) contribute immensely in disease propagation. These nano-vesicles, generated from plasma membrane
相关内容
Product Information Sheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持