SAB1300104
Anti-CAMK2δ-like (C-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-CAMK2G, Anti-CaM-kinase II γ chain, Anti-Calcium/calmodulin-dependent protein kinase type II γ chain, CaM kinase II γ subunit, CaMK-II γ subunit
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, human, mouse
技术
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CAMK2(818)
一般描述
Ca2+/calmodulin-dependent kinase II γ (CaMKIIγ) gene is mapped to human chromosome 10q22.2. The encoded protein is a multifunctional serine/threonine kinase and is specific to various substrates. CaMKII contains four isoforms: CaMKIIα/β/γ/δ. CaMKII is ubiquitously expressed in humans. The protein consists of an N-terminal catalytic domain, a regulatory domain, and a C-terminal association domain.
CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
The previously assigned protein identifier O15378 has been merged into Q13555. Full details can be found on the UniProt database.
The previously assigned protein identifier O15378 has been merged into Q13555. Full details can be found on the UniProt database.
免疫原
CAMK2 (NP_751911, 314-348)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-term region of human CAMK2 delta-like.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-term region of human CAMK2 delta-like.
生化/生理作用
CaMKIIγ (Ca2+/calmodulin-dependent kinase II γ) is mostly expressed in tumor-initiating cells. CaMKIIγ regulates the progression of cancer cells in leukemia, lung cancer, and liver cancer. CaMKIIγ participates in the β-catenin, Stat3 (signal transducer and activator of transcription 3), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signal pathways..
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Lam C Tsoi et al.
Nature communications, 6, 7001-7001 (2015-05-06)
Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling
Shoujie Chai et al.
Oncotarget, 6(18), 16069-16083 (2015-05-13)
Highly tumorigenic stem-like cells, considered tumor-initiating cells (TICs), are the main cause of lung cancer initiation, relapse, and drug resistance. In this study, we identified that Ca2+/calmodulin-dependent protein kinase IIγ (CaMKIIγ) was aberrantly expressed in highly tumorigenic stem-like lung cancer
Thomas J Hund et al.
Trends in cardiovascular medicine, 25(5), 392-397 (2015-01-13)
Protein phosphorylation is a central mechanism in vertebrates for the regulation of signaling. With regard to the cardiovascular system, phosphorylation of myocyte targets is critical for the regulation of excitation contraction coupling, metabolism, intracellular calcium regulation, mitochondrial activity, transcriptional regulation
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