Anti-drh-1 (N-term) antibody produced in rabbit

Human Drh-1 protein possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. The 21-nucleotide small temporal RNA (stRNA) let7 regulates developmental timing in C. elegans and probably in other bilateral animals. In Drosophila, a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let7 stRNA. Targeted disruption in cultured human cells of the mRNA encoding the enzyme Drh-1, which acts in the RNA interference pathway, leads to accumulation of the LET7 precursor. Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA processing enzyme Drh-1 to produce the active small RNA component that represses gene expression.

DRH (NP_501018, 12-46)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of C. elegans Drh-1.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.