Anti-CHIP (STUB1) (C-term) antibody produced in rabbit

CHIP (C-terminus of HSP70-interacting protein) gene is located in human chromosome 16p13.3. This gene codes for a E3 ubiquitin ligase. The bioactive site of the protein includes three tandem repeats of the tetratricopeptide motif at the N-terminal, a C-terminal U-box domain and a charged coiled-coil region in between the two. CHIP is ubiquitously expressed.

CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson′s disease.

CHIP (Q969U2, 208-242)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the C-term of human CHIP (STUB1).

CHIP (C-terminus of HSP70-interacting protein) induces ubiquitination and proteasomal degradation of proteins sent by chaperone partners for removal via endocytic-lysosomal machinery. CHIP interacts with molecular chaperones and degradation machineries to maintain protein homeostasis within the cell. Lack of CHIP increases the process of aging, indicating that the gene might mediate long living. CHIP prevents the accumulation of protein aggregates in age-related disease conditions. CHIP is responsible for the degradation of CD166, a cancer stem-like cell (CSC) marker in head and neck cancer. Therefore, CHIP is suggested as an option for the diagnosis of head and neck cancer.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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