clone
polyclonal
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
form
buffered aqueous solution
mol wt
27kDa
species reactivity
horse, rat, rabbit, dog, mouse, human, pig
concentration
0.5 mg - 1 mg/mL
technique(s)
immunoblotting: suitable, immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BDNF(627)
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General description
脑源性神经营养因子（BDNF）基因定位于人类染色体 11p14.1 上。BDNF是生长因子中神经营养蛋白家族的成员，该 该基因编码前体蛋白proBDNF。成熟的BDNF（mBDNF）是通过proBDNF的翻译后切割合成的。proBDNF 和 mBDNF 在细胞信号传导中都起着至关重要的作用。
Immunogen
指向人 BDNF 中间区域的合成肽
Application
兔抗 BDNF 抗体可用于免疫组化和免疫印迹。
Biochem/physiol Actions
脑源性神经营养因子（BDNF）参与人类的海马功能和言语情节记忆。因此，BDNF 基因表达的变异会改变这些神经功能。BDNF在血管功能中也起着至关重要的作用，并通过特异性受体原肌球蛋白相关激酶B（TrkB）参与血管生成。它参与了阿尔茨海默′病的发病机制。ProBDNF 与 p75 神经营养因子受体相互作用，导致海马体的长期抑制。
Physical form
在含 0.09% (w/v) 叠氮化钠和 2% 蔗糖的 1x PBS 缓冲液中提供纯化抗体。
Other Notes
合成肽位于以下区域：EWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEG
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism.
Lemos JR Jr, et al.
Physiological Genomics, 48, 116-123 (2016)
Kíssila Rabelo et al.
Frontiers in immunology, 11, 2146-2146 (2020-09-29)
In Brazil, an epidemic of Zika virus (ZIKV) infections was declared in 2015 that coincided with alarming reports of microcephaly in newborns associated with mother infection. Although the virus has placental tropism, changes in the tissue morphology and immunity of
Bin Liu et al.
Journal of ovarian research, 16(1), 83-83 (2023-04-28)
Brain-derived neurotrophic factor (BDNF) plays an important role in ovarian function including follicle development and oocyte maturation, and embryonic development. However, whether BDNF treatment can reimpose ovarian aging and impaired fertility remains elusive. In this study, we investigated the reproductive
Daniela Rodrigues-Amorim et al.
Frontiers in psychiatry, 10, 885-885 (2019-12-19)
Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics
Ting-Ting Liu et al.
Oncology letters, 15(1), 533-537 (2018-02-03)
Neurotrophic factors (NTFs) are well known to serve critical functions in neural survival, neurite growth and cell differentiation in vivo and in vitro. Previous progress has indicated that nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), two NTF family
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