SAB4100228
Monoclonal Anti-PTPRE antibody produced in mouse
clone PTPRE-B186, culture supernatant
别名:
AntiHPTPE, AntiPTPE, AntiProtein tyrosine phosphatase, receptor type, E, AntiR-PTP-EPSILON
生物来源
mouse
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
PTPRE-B186, monoclonal
表单
aqueous solution
分子量
antigen predicted mol wt 80.6 kDa
种属反应性
human
技术
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... PTPRE(5791)
一般描述
PTPRE (Protein tyrosine phosphatase, receptor type, E) is a transmembrane protein consisting of a short extracellular domain and two tandemly repeated intracellular PTPase domains. It is located on chromosome 10q26 in humans. It is expressed in testis, brain, lung and lymph node. Its expression also has been observed during neuronal differentiation and in murine mammary tumour cells. It has an isoform consisting of an N-terminal catalytic, active phosphatase domain 1 (PD1).
免疫原
PTPRE purified recombinant protein
应用
Monoclonal Anti-PTPRE antibody produced in mouse is suitable for western blot assay.
生化/生理作用
PTPRE (Protein tyrosine phosphatase, receptor type, E) is associated with various signalling pathways including down regulation of insulin receptor signalling and Janus kinase (Jak)-STAT inhibition signalling pathway. It also plays an important role in the regulation of ERK1/2 pathway by emerging as a phosphatase through its catalytic activity. Study shows that it may play an accessory role in tumour development.
外形
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization.
A M van den Maagdenberg et al.
Genomics, 30(1), 128-129 (1995-11-01)
T Wabakken et al.
Scandinavian journal of immunology, 56(3), 276-285 (2002-08-24)
This report describes the identification and characterization of a novel cytoplasmic isoform of human protein tyrosine phosphatase epsilon (PTPepsilon). The novel isoform, denoted cyt-PTPepsilonPD1, displays only the N-terminal catalytic, active phosphatase domain 1 (PD1) which is common in all known
T Wabakken et al.
Scandinavian journal of immunology, 56(2), 195-203 (2002-07-18)
The expression of protein tyrosine phosphatase epsilon (PTPepsilon) was studied in human tissues and blood cells. High mRNA expression was observed in peripheral blood leucocytes, particularly in monocytes and granulocytes which revealed at least four distinct transcripts. In lymphocytes, PTPepsilon
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