Anti-XRN1 antibody produced in rabbit

5→3′ exoribonuclease 1 (XRN1) is a cytoplasmic enzyme, encoded by the gene mapped to human chromosome 3q23. The encoded protein has a molecular mass of 175kDa and is a member of XRN family of exoribonucleases. It is mainly localized in cytoplasmic P- bodies.

Anti-XRN1 antibody produced in rabbit has been used in:

• immunostaining
• immunoblotting
• immunofluorescence.

5→3′ exoribonuclease 1 (XRN1) catalyzes the degradation of decapped (5′ monophosphorylated) RNA in the 5′→3′ direction. In addition, it also degrades tRNA (iMet) that is distributed in the cytoplasm. XRN1 is implicated in the modulation of dsRNA accumulation and dsRNA-responsive innate immune effectors. The encoded protein also plays an essential role in maintaining the fidelity of cellular RNA turnover in eukaryotes. XRN1 is required for proper bone formation in humans. Therefore, mutation in the gene leads to development of osteosarcoma.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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