SAB4200028
Anti-XRN1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-5′-3′ exoribonuclease 1, Anti-DKFZp434P0721, Anti-DKFZp686B22225, Anti-DKFZp686F19113, Anti-FLJ41903
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
9
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~195 kDa
species reactivity
mouse, human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed NIH-3T3 cells, western blot: 2-4 μg/mL using nuclear extract of HEK-293T
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... XRN1(54464)
mouse ... Xrn1(24127)
rat ... Xrn1(300944)
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General description
5→3′ exoribonuclease 1 (XRN1) is a cytoplasmic enzyme, encoded by the gene mapped to human chromosome 3q23. The encoded protein has a molecular mass of 175kDa and is a member of XRN family of exoribonucleases. It is mainly localized in cytoplasmic P- bodies.
Application
Anti-XRN1 antibody produced in rabbit has been used in:
- immunostaining
- immunoblotting
- immunofluorescence.
Biochem/physiol Actions
5→3′ exoribonuclease 1 (XRN1) catalyzes the degradation of decapped (5′ monophosphorylated) RNA in the 5′→3′ direction. In addition, it also degrades tRNA (iMet) that is distributed in the cytoplasm. XRN1 is implicated in the modulation of dsRNA accumulation and dsRNA-responsive innate immune effectors. The encoded protein also plays an essential role in maintaining the fidelity of cellular RNA turnover in eukaryotes. XRN1 is required for proper bone formation in humans. Therefore, mutation in the gene leads to development of osteosarcoma.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins
Janas MM, et al.
RNA, 18(11), 2041-2055 (2012)
Degradation of initiator tRNAMet by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells.
Watanabe K
Nucleic Acids Research, 41, 4671-4685 (2013)
Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses.
Burgess HM and Mohr
Cell host & microbe, 17, 332-344 (2015)
Comparison between osteoblasts derived from human dental pulp stem cells and osteosarcoma cell lines.
Palmieri A
Cell Biology International, 32, 733-733 (2008)
XRN 5'?3' exoribonucleases: structure, mechanisms and functions.
Nagarajan VK
Biochimica et Biophysica Acta, 1829, 590-603 (2013)
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