Anti-BMI1 antibody produced in rabbit

The human proto-oncogene BMI1 (also known as Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

Anti-BMI1 antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~37 kDa) and immunofluorescence.

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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